CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD391
Family Name Adenosine receptor A3 Ligand CF101 Family
No. of Seeds 24 No. of Other Members 560
Family Centroid CFAMM00154277 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Adenosine receptor A3 and Pigment epithelium-derived factor Binder Superfamily
Class Class 652

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
P2Y purinoceptor 12 Inhibitor Brilinta Family 1 1
Pigment epithelium-derived factor Inhibitor Adpedr Family 2 112
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Adenosine receptor A1 Ligand SLV320 Family 6 79
GP-531 family 1 33
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
3-hydroxy-3-methylglutaryl-coenzyme A reductase and Alcohol de... 7 10
Equilibrative nucleoside/nucleobase transporter Inhibitor Nitr... 23 98
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine kinase inhibitor GP683 family 12 7
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 9
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3S,... 1 2
Uracil nucleotide/cysteinyl leukotriene receptor ligand azane;... 1 0
Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) ... 24 9
Adenosine receptor A3 ligand SureCN6211758 family 5 10
Adenosine receptor A1 and Adenosine receptor A2a ligand (2S,3S... 2 16
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 12 17
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 8 10
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 6 17
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 0
Adenosine receptor A3 ligand (1R,2R,3S,4R,5S)-4-[2-[2-(2-chlor... 5 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 11 4
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 7 4
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 10
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A3 ligand (2R,3R,4S)-2-[6-[(3-bromophenyl)m... 3 0
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 14 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 0
Adenosine receptor A1 ligand 3-chloro-N-[(2S,3R,4R,5R)-5-[6-(c... 1 0
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 3
Adenosine receptor A2a and Adenosine receptor A2b ligand Cgs-2... 1 2
P2X purinoceptor 1 and P2X purinoceptor 3 inhibitor [(2R,3R,4R... 1 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3R,... 1 0
Adenosine receptor A1 ligand (2,5-dioxopyrrolidin-1-yl) 2-[4-[... 3 0
cAMP-dependent protein kinase catalytic subunit alpha inhibito... 1 5
Adenosine receptor A1 ligand (2-bromophenyl)methyl (1S,3R,4S)-... 1 0
Equilibrative nucleoside transporter 1 inhibitor N-[6-[2-[[(2S... 2 0
Carboxypeptidase B2 and Carboxypeptidase B inhibitor SureCN648... 4 1
Adenosine receptor A2a and Adenosine receptor A3 ligand SureCN... 4 3
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand (3S,4... 3 2
Adenosine receptor A2a ligand (1S,2R,3S,4R)-4-[6-amino-2-[2-(4... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand (3R,4... 7 3
Adenosine receptor A1 and Adenosine receptor A2b ligand (2R,3R... 1 0
P2Y purinoceptor 12 inhibitor [(3aR,4R,6R,6aR)-4-[6-(ethylcarb... 2 4
DNA polymerase III PolC-type and DNA polymerase III subunit al... 11 10
78 kDa glucose-regulated protein inhibitor 4-[[(2R,3S,4R,5R)-5... 1 0
78 kDa glucose-regulated protein and Heat shock cognate 71 kDa... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00154436 CHEMBL516058 Bioactive (2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-N-(cyclopropylmethyl)-3,4-dihydroxyoxolane-2-carboxamide
CFAMM00154293 CHEMBL2113613 Bioactive (2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]oxolane-2-carboxamide
CFAMM00154520 CHEMBL2113557 Bioactive (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-methylsulfanylpurin-9-yl]-N-methyloxolane-2-carboxamide
CFAMM00154836 CHEMBL605266 Bioactive 2-[(2R,3R,4S)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]-N-methylacetamide
CFAMM00154829 CHEMBL486171 Bioactive (2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
CFAMM00154647 CHEMBL436255 Bioactive 5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3-fluoro-4-hydroxy-N-methyloxolane-2-carboxamide
CFAMM00154542 CHEMBL393362 Bioactive (2S,3S,4R,5R)-3-hydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-4-methoxy-N-methyloxolane-2-carboxamide
CFAMM00154679 CHEMBL605054 Bioactive 2-[(2R,3R,4S)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]oxolan-2-yl]-N-methylacetamide
CFAMM00154579 CHEMBL2094086 Bioactive (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[[(2R)-1-phenylbutan-2-yl]amino]purin-9-yl]oxolane-2-carboxylic acid
CFAMM00154422 CHEMBL2113562 Bioactive (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-(methylamino)purin-9-yl]-N-methyloxolane-2-carboxamide
CFAMM00154860 CHEMBL486374 Bioactive (2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide
CFAMM00154578 CHEMBL2094084 Bioactive (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[[(2R)-1-phenylpropan-2-yl]amino]purin-9-yl]oxolane-2-carboxylic acid
CFAMM00154481 DCL001171 Clinical Trial Drug CF102
CFAMM00154277 DCL000749 Clinical Trial Drug CF101
CFAMM00154670 DNC004567 Investigative Drug CGS-21680
CFAMM00154489 DNC000062 Investigative Drug 3-IB-MECA
CFAMM00154274 DNC000411 Investigative Drug CGS 21680
CFAMM00154514 DNC007773 Investigative Drug N6-(3-Iodobenzyl)-2'-O-methyladenosine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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