CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD393
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Cilomilast Family
No. of Seeds 9 No. of Other Members 123
Family Centroid CFAMM00154960 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Sodium channel Ligand Permethrin Superfamily
Class Class 614

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Sodium channel Ligand Permethrin Family 1 25
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Tyrosine-protein phosphatase non-receptor type 1 Ligand Phelli... 1 1
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Prostaglandin D2 receptor 2 Ligand 2-(4-cyano-2-cyclohexylphen... 6 3
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 11
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 4 2
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor 2-[4-... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
NS5B protein inhibitor SureCN3988565 family 2 4
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Arachidonate 5-lipoxygenase inhibitor 5-(1,3-benzodioxol-5-yl)... 2 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Fyn in... 1 2
Cytochrome P450 2D6 inhibitor AGN-PC-0AKMFJ family 1 1
Integrase inhibitor AC1NX3RZ family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Fatty Acid Esters Metabolite Fenvalerate Family 1 3
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Phenols and Derivatives Metabolite 6-Gingesulfonic acid Family 1 2
Prenol Lipids Metabolite Rosmadial Family 1 0
Acenes Metabolite Musanolone D Family 2 1
Putative NP ZINC31165975 Family 4 0
2-benzoyl-3-(3,4-dimethoxyphenyl)-2-ethylcyclopropane-1,1-dica... 4 0
1,3-dimethylcyclohepta[c]furan-8-one NP 6-(4-hydroxy-3-iodo-5-... 13 1
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00155072 CHEMBL220060 Bioactive SureCN1400278
CFAMM00154880 CHEMBL220430 Bioactive SureCN1400329
CFAMM00155000 CHEMBL27107 Bioactive CHEMBL26760
CFAMM00155036 CHEMBL167638 Bioactive SureCN6811981
CFAMM00154937 CHEMBL220508 Bioactive SureCN1400780
CFAMM00155056 CHEMBL264369 Bioactive (3aS,6aR)-5-cyano-5-[3-(2,3-dihydro-1H-inden-2-yloxy)-4-methoxyphenyl]-2,3,3a,4,6,6a-hexahydro-1H-pentalene-2-carboxylic acid
CFAMM00154872 CHEMBL220681 Bioactive SureCN1400818
CFAMM00154960 DCL000752 Clinical Trial Drug Cilomilast

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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