CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD397
Family Name Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Family
No. of Seeds 5 No. of Other Members 74
Family Centroid CFAMM00155209 Functional Category Clinical Trial Drug with Natural Product
Superfamily Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Metabotropic glutamate receptor 5 Ligand 2-(3-chlorobenzyloxy)... 2 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... 2 5
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Bloom syndrome protein and Prelamin-A/C inhibitor Dubinidine f... 1 17
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Metabotropic glutamate receptor 5 ligand 2-chloro-6-[(2-methyl... 1 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 2,... 1 8
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 4
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
2,4,6-trimethyl-2,3-dihydrofuro[3,2-c]quinoline NP ZINC0009476... 4 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00155196 CHEMBL408824 Bioactive SureCN5843983
CFAMM00155207 CHEMBL271324 Bioactive SureCN5844212
CFAMM00155209 DCL000757 Clinical Trial Drug CP-316,311
CFAMM00155217 DNC013525 Investigative Drug CP-376395
CFAMM00155211 DNC006855 Investigative Drug 2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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