CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD401
Family Name Substance-P receptor Ligand DA-5018 Family
No. of Seeds 14 No. of Other Members 73
Family Centroid CFAMM00155391 Functional Category Clinical Trial Drug with Natural Product
Superfamily Substance-P receptor Binder Superfamily
Class Class 333

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(3) dopamine receptor Ligand U-99194A Family 7 33
Ivabradine family 1 11
Dapoxetine family 3 40
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Peroxisome proliferator-activated receptor gamma Ligand Ciglit... 1 31
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Transient receptor potential cation channel subfamily V member... 3 18
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Acetylcholinesterase inhibitor (5S)-5-[4-(5,6-dimethoxy-3-oxo-... 1 3
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 4-(3... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 4 4
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 5
Renin inhibitor (4S,5S,7S)-5-amino-N-butyl-7-[[4-tert-butyl-3-... 2 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor meth... 1 0
Putative NP ZINC14589285 Family 2 1
Putative NP ZINC04041531 Family 40 0
3-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)amino... 3 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
NP N-(3,4-dimethoxyphenethyl)-2-(2-(hydroxymethyl)-5-methoxy-4... 1 0
Putative NP ZINC02099241 Family 12 0
3-benzazepin-2-one NP 7,8-dimethoxy-1h-benzo[d]azepin-2(3h)-on... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00155397 CHEMBL260131 Bioactive (1S,2R)-2-(aminomethyl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-ethyl-N-prop-2-ynylcyclopropane-1-carboxamide
CFAMM00155375 CHEMBL408016 Bioactive (1S,2R)-2-(aminomethyl)-N-(cyclopropylmethyl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-ethylcyclopropane-1-carboxamide
CFAMM00155384 CHEMBL401677 Bioactive (1S,2R)-2-(aminomethyl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-ethenyl-N-ethylcyclopropane-1-carboxamide
CFAMM00155409 CHEMBL402441 Bioactive (1S,2R)-2-(aminomethyl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N,N-bis(prop-2-ynyl)cyclopropane-1-carboxamide
CFAMM00155391 DCL000763 Clinical Trial Drug DA-5018
CFAMM00155355 DNC000017 Investigative Drug (S)-Rolipram
CFAMM00155369 DNC000014 Investigative Drug (R)-Rolipram

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26194 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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