CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD405
Family Name Translocator protein Inhibitor Dextofisopam Family
No. of Seeds 3 No. of Other Members 250
Family Centroid CFAMM00155638 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Translocator protein Inhibitor Dextofisopam Superfamily
Class Class 1081

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Tyrosinase Inhibitor Monobenzone Family 6 197
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
TS-071 family 8 36
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Endothelin-1 receptor Ligand PD156707 Family 41 211
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor Fila... 9 9
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Tubulin beta chain Inhibitor 3-bromo-4,4',5-trimethoxy-(z)-sti... 1 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Epidermal growth factor receptor Ligand 4-(2-nitrovinyl)benzen... 3 1
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Carbonic anhydrase 2 Inhibitor Guaiacol Family 1 14
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Aromatase Inhibitor NSC-122427 Family 1 0
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Geranylgeranyl pyrophosphate synthase inhibitor [1-Hydroxy-2-(... 1 2
Prostaglandin G/H synthase 2 inhibitor AGN-PC-04VJ4H family 1 2
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E,... 1 0
Prostaglandin G/H synthase 2 inhibitor (4E)-3-(4-chlorophenyl)... 1 0
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
NP (1r,2r,4s)-2-(2-methoxyphenyl)-1,3,3-trimethylbicyclo[2.2.1... 3 0
1-(4-chlorophenyl)-6,7-dimethoxy-3,3-dimethyl-4H-isoquinoline ... 1 0
3-(2,3-dihydro-1,4-benzodioxin-6-yl)chromene-4-thione NP 3-(2,... 1 0
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
NP 4-(3,4-dimethoxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)but... 2 3
NP Agn-pc-05cqe7 Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00155621 DCL001082 Clinical Trial Drug Terameprocol
CFAMM00155638 DCL000772 Clinical Trial Drug Dextofisopam
CFAMM00155874 DNC007547 Investigative Drug DI-O-METHYLENDIANDRIN A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543