CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD407
Family Name Substance-K receptor and Substance-P receptor Ligand DNK-333 Family
No. of Seeds 15 No. of Other Members 95
Family Centroid CFAMM00156107 Functional Category Clinical Trial Drug
Superfamily Substance-K receptor and Substance-P receptor Ligand DNK-333 Superfamily
Class Class 496

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Phospholipase D1 Inhibitor Halopemide Family 17 111
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand CH... 3 5
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 1 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Substance-K receptor and Substance-P receptor ligand N-[(2Z,3R... 26 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Prothrombin inhibitor SureCN6921523 family 4 1
Substance-K receptor ligand SureCN3083325 family 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[(2,5-di... 3 2
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
B1 bradykinin receptor ligand N-[(1R)-1-[4-(3-chloro-2-propano... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Substance-P receptor ligand 2-[bis(4-hydroxy-4-phenylpiperidin... 2 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2,6-d... 1 1
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
Substance-P receptor ligand AGN-PC-074VYH family 4 0
Substance-P receptor ligand AGN-PC-074VYG family 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Putative Bioactive [3-[benzoyl(hydroxy)amino]-1-(3,4-dichlorop... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00156057 CHEMBL104954 Bioactive N-[(E,2R)-1-(4-chlorophenyl)-5-oxo-5-[[(3R)-2-oxoazepan-3-yl]amino]pent-3-en-2-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide
CFAMM00156088 CHEMBL139167 Bioactive AGN-PC-075NU5
CFAMM00156118 CHEMBL140023 Bioactive AGN-PC-075NP6
CFAMM00156063 CHEMBL479642 Bioactive AGN-PC-03L0YW
CFAMM00156049 CHEMBL361199 Bioactive 3,4-dichloro-N-[2-[methyl-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]amino]-2-oxoethyl]benzamide
CFAMM00156016 CHEMBL105600 Bioactive N-[(E,2R)-5-[(1-carbamoylcyclohexyl)amino]-1-(4-chlorophenyl)-5-oxopent-3-en-2-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide
CFAMM00156125 CHEMBL35857 Bioactive N-[(E)-1-(4-chlorophenyl)-5-oxo-5-[(2-oxoazepan-3-yl)amino]pent-3-en-2-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide
CFAMM00156086 CHEMBL2115343 Bioactive N-[(E,2R)-1-(4-chlorophenyl)-5-oxo-5-[[(3S)-2-oxoazepan-3-yl]amino]pent-3-en-2-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide
CFAMM00156060 CHEMBL318606 Bioactive 3-[[[3,5-bis(trifluoromethyl)benzoyl]-methylamino]-[(3,4-dichlorophenyl)methyl]amino]-N-[(3R)-2-oxoazepan-3-yl]propanamide
CFAMM00156039 CHEMBL2112212 Bioactive 3-[[3,5-bis(trifluoromethyl)benzoyl]-methylamino]-4-(3,4-dichlorophenyl)-N-[(3R)-2-oxoazepan-3-yl]benzamide
CFAMM00156107 DCL000776 Clinical Trial Drug DNK-333

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27255 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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