CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD408
Family Name Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21947 Family
No. of Seeds 16 No. of Other Members 89
Family Centroid CFAMM00156225 Functional Category Clinical Trial Drug
Superfamily Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21947 Superfamily
Class Class 48

Cousin Family NamesSeedsMembers
Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Dopamine reuptake and Noradrenergic re-uptake Inhibitor GSK372... 7 61
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Zicronapine family 43 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 24
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Sodium-dependent dopamine transporter inhibitor [3-(4-chloroph... 1 1
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 9 3
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Kinesin-like protein KIF11 inhibitor 4-(4-chlorophenyl)-4,4-di... 1 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00156188 CHEMBL451527 Bioactive (1S,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
CFAMM00156202 CHEMBL600645 Bioactive (1R,5S,6S)-1-(3,4-dichlorophenyl)-6-propyl-3-azabicyclo[3.1.0]hexane
CFAMM00156223 CHEMBL2322000 Bioactive (3S)-3-(3,4-dichlorophenyl)-2,3,4,7-tetrahydro-1H-azepine
CFAMM00156190 CHEMBL611990 Bioactive SureCN13486579
CFAMM00156196 CHEMBL2321999 Bioactive (3R)-3-(3,4-dichlorophenyl)-2,3,4,7-tetrahydro-1H-azepine
CFAMM00156195 CHEMBL2321998 Bioactive 3-(3,4-dichlorophenyl)-2,3,4,7-tetrahydro-1H-azepine
CFAMM00156225 DCL000779 Clinical Trial Drug DOV 21947
CFAMM00156148 DNCL003085 Clinical Trial Drug Amitifadine
CFAMM00156206 DCL000780 Clinical Trial Drug DOV-216303
CFAMM00156159 DNC007036 Investigative Drug (RS/SR)-2-[1-(3,4-dichlorophenyl)butyl]piperidine
CFAMM00156198 DNC014150 Investigative Drug 3-(3,4-dichlorophenyl)-2-nortropene

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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