CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFCD41
Family Name Transient receptor potential cation channel subfamily V member 1 Ligand Bctc Family
No. of Seeds 16 No. of Other Members 295
Family Centroid CFAMM00130171 Functional Category Clinical Trial Drug with Natural Product
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand Bctc Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Triprolidine Family 19 316
Transient receptor potential cation channel subfamily V member... 15 158
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Transient receptor potential cation channel subfamily V member... 2 26
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 29
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 1 2
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Urotensin-2 receptor Ligand Palosuran Family 4 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Reverse transcriptase Inhibitor PT-102 Family 8 12
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Reverse transcriptase Inhibitor PT-109 Family 6 7
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN7371121 family 13 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Transient receptor potential cation channel subfamily V member... 3 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Metabotropic glutamate receptor 5 ligand [(E)-(1,2-dicyclohexy... 1 4
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 1 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Coagulation factor X inhibitor (3R,4R)-3-N-(5-chloropyridin-2-... 3 6
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 5 3
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Prostaglandin E synthase and Aldo-keto reductase family 1 memb... 3 12
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BGV ... 1 0
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 7
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Lysosomal Pro-X carboxypeptidase inhibitor methyl N-[4-[[6-[[(... 1 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Corticotropin-releasing factor receptor 1 ligand 4-(1-cyclopro... 3 0
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 5 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
D(4) dopamine receptor ligand (1Z)-1-hydroxyimino-1-(3-methylp... 1 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 1 2
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Translocator protein inhibitor CHEMBL2331870 family 2 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
B1 bradykinin receptor ligand N-[2-[[4-(2-chlorophenyl)-4-cyan... 2 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 7 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
Integrin alpha-V and Integrin beta-6 inhibitor SureCN12259087 ... 3 4
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Adenosine kinase inhibitor SureCN8248615 family 2 3
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand (E)-1... 1 2
Receptor-type tyrosine-protein kinase FLT3 ligand 4-[6-amino-5... 1 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Transient receptor potential cation channel subfamily V member... 1 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Neuropeptide Y receptor type 5 ligand AGN-PC-07CNLC family 1 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(4-fluoropheny... 1 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Androgen receptor ligand 4-(1-benzyl-2-oxoimidazo[4,5-b]pyridi... 1 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
N-formyl peptide receptor 2 ligand 1-(1-methyl-3-oxo-5-propan-... 3 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
Transient receptor potential cation channel subfamily V member... 2 0
P2X purinoceptor 7 inhibitor 1-[3-[4-chloro-3-(cycloheptylmeth... 1 0
Cannabinoid receptor 2 ligand 4-[5-(2,3-dichlorophenyl)pyridin... 2 4
Acetylcholinesterase inhibitor AGN-PC-0806LR family 1 0
Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... 1 2
Interstitial collagenase inhibitor AGN-PC-03RA86 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00130287 CHEMBL1223856 Bioactive AGN-PC-00BRQ8
CFAMM00130434 CHEMBL1681865 Bioactive SureCN13789199
CFAMM00130203 CHEMBL606035 Bioactive AGN-PC-04ELHU
CFAMM00130440 CHEMBL333196 Bioactive SureCN14423741
CFAMM00130455 CHEMBL365377 Bioactive 1,6-naphthyridine 37
CFAMM00130426 CHEMBL179739 Bioactive N-[4-(trifluoromethyl)phenyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
CFAMM00130298 CHEMBL367156 Bioactive AGN-PC-0074TU
CFAMM00130399 CHEMBL191389 Bioactive 1,6-naphthyridine 34
CFAMM00130346 CHEMBL1223800 Bioactive AGN-PC-00A9TH
CFAMM00130459 CHEMBL1091836 Bioactive AGN-PC-07ZC1Z
CFAMM00130230 CHEMBL482835 Bioactive AGN-PC-009TVJ
CFAMM00130175 CHEMBL121308 Bioactive SureCN13930737
CFAMM00130222 CHEMBL425410 Bioactive 3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,4R,5S)-1-pyridin-3-yl-4-bicyclo[3.1.0]hexanyl]urea
CFAMM00130330 CHEMBL572909 Bioactive AGN-PC-07CNLA
CFAMM00130171 DCL000063 Clinical Trial Drug BCTC

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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