CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD421
Family Name Substance-P receptor Ligand Ezlopitant Family
No. of Seeds 10 No. of Other Members 207
Family Centroid CFAMM00157284 Functional Category Clinical Trial Drug with Natural Product
Superfamily Substance-P receptor Ligand Ezlopitant Superfamily
Class Class 120

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Zucapsacin family 7 177
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
D(4) dopamine receptor Ligand PD-165167 Family 2 96
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 6
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
D(2) dopamine receptor Ligand Epidepride Family 31 66
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Amine oxidase [flavin-containing] B Inhibitor (r)-n2-{4-[(3-ch... 3 0
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Substance-P receptor ligand (2S,3S)-2-(3-chlorophenyl)-N-[(2,4... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Substance-P receptor ligand SureCN7160908 family 2 0
Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihy... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Substance-P receptor and Potassium voltage-gated channel subfa... 1 0
Substance-P receptor ligand AGN-PC-075ZHA family 4 2
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 3 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sigma non-opioid intracellular receptor 1 ligand (1S,4R,5R)-7-... 2 7
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Substance-P receptor ligand CP 141938 family 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Substance-P receptor ligand SureCN6400808 family 2 0
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
Mu-type opioid receptor ligand 2-[[2-[(2R)-2-ethyl-4-(4-fluoro... 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sigma non-opioid intracellular receptor 1 ligand (1R,5S)-9-[(4... 3 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 2 2
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0A9S9E... 1 0
Acetylcholinesterase and Cholinesterase inhibitor (8E)-4-(2-me... 1 0
Sterol O-acyltransferase 1 inhibitor AGN-PC-073SE1 family 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BF6 family 1 1
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0
NP Agn-pc-05fhfm Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00157284 DCL000800 Clinical Trial Drug Ezlopitant
CFAMM00157205 DNC003722 Investigative Drug CP-96345
CFAMM00157168 DNC006805 Investigative Drug 1-(2-(2-ethoxyphenyl)-1-phenylethyl)piperazine
CFAMM00157251 DNC000468 Investigative Drug CP-100263
CFAMM00157136 DNC005428 Investigative Drug MCL-129
CFAMM00157070 DNC006822 Investigative Drug 1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine
CFAMM00157215 DNC008297 Investigative Drug PF-526014
CFAMM00157179 DNC004179 Investigative Drug CP-99994
CFAMM00157098 DNC006813 Investigative Drug 1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine
CFAMM00157193 DNC000478 Investigative Drug CP-99,994

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27284 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543