CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Dopamine reuptake and Noradrenergic re-uptake Inhibitor GSK372475 Family
No. of Seeds 7 No. of Other Members 61
Family Centroid CFAMM00157378 Functional Category Clinical Trial Drug
Superfamily Dopamine reuptake and Noradrenergic re-uptake Inhibitor GSK372475 Superfamily
Class Class 961

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 1 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sodium-dependent serotonin transporter and Transporter inhibit... 6 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Sodium-dependent dopamine transporter inhibitor (1R)-1-[(3S,4S... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0


External ID

Functional Category

Molecule Name

CFAMM00157403 CHEMBL1173607 Bioactive (6R,11S)-11-(3,4-dichlorophenyl)-2-oxa-8-azaspiro[5.5]undecane
CFAMM00157387 CHEMBL2407333 Bioactive 4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine;hydrochloride
CFAMM00157345 CHEMBL1173416 Bioactive (1S,3S,6R)-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-methyl-4-azabicyclo[4.1.0]heptane
CFAMM00157378 DCL000824 Clinical Trial Drug GSK372475
CFAMM00157354 DNC014479 Investigative Drug (+/-)-threo-3',4'-Dichlororitalinol methyl ether
CFAMM00157353 DNC014478 Investigative Drug (+/-)-threo-3',4'-Dichlororitalinol
CFAMM00157406 DNC013265 Investigative Drug threo-3,4-dichlororitalinol hydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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