CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Alpha-2 adrenergic receptor Ligand Idazoxan Family
No. of Seeds 6 No. of Other Members 26
Family Centroid CFAMM00157518 Functional Category Clinical Trial Drug
Superfamily Adenosine receptor A2a and Alpha-2 adrenergic receptor Binder Superfamily
Class Class 1080

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor ligand Clonidine derivative Lofexi... 2 2
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Adenosine receptor A2a Ligand Dexefaroxan Family 11 46
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Beta-lactamase inhibitor CHEMBL1566697 family 1 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 4 0


External ID

Functional Category

Molecule Name

CFAMM00157522 CHEMBL544664 Bioactive AGN-PC-00KK1U
CFAMM00157525 CHEMBL61325 Bioactive SureCN10809046
CFAMM00157518 DCL000841 Clinical Trial Drug Idazoxan
CFAMM00157544 DNC012444 Investigative Drug RX-821002
CFAMM00157527 DNC012433 Investigative Drug 2-Phenoxymethyl-4,5-dihydro-1H-imidazole

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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