CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFCD445
Family Name D(1B) dopamine receptor Ligand LE-300 Family
No. of Seeds 65 No. of Other Members 452
Family Centroid CFAMM00157948 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily D(1B) dopamine receptor Ligand LE-300 Superfamily
Class Class 1105

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 15 158
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Substance-P receptor Ligand GSK424887 Family 8 184
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
E7820 family 9 56
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Gp29 Inhibitor Tmpyp4 Family 1 3
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Acetylcholinesterase Inhibitor 3-[2-(1-benzyl-piperidin-4-yl)-... 2 9
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Mast/stem cell growth factor receptor Kit Ligand 9-bromo-5,11-... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Histamine H4 receptor Ligand A-943931 Family 14 11
Glucocorticoid receptor and Oxysterols receptor LXR-alpha Liga... 4 13
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Urotensin-2 receptor Ligand Palosuran Family 4 4
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Kinesin-like protein KIF11 Inhibitor 9h-carbazole-2-carbaldehy... 1 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 1
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 7,12-d... 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Trypsin Inhibitor 4-(5-nitro-indol-1-ylmethyl)-benzamidine Family 2 0
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1D ligand SureCN7253308 family 2 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-[2-(2-h... 1 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Progesterone receptor ligand N-[4-(5-cyano-1-methylpyrrol-2-yl... 6 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 7
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Capsid scaffolding protein inhibitor AC1O583J family 5 1
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 7 ligand 6-bromo-1-[2-[4-(cyclopr... 2 4
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Transient receptor potential cation channel subfamily V member... 1 0
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand SureCN1... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Protein kinase C eta type and Protein kinase C epsilon type in... 1 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 1 0
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Lysine-specific demethylase 4E and Lethal(3)malignant brain tu... 1 1
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0
Lactoylglutathione lyase inhibitor 1-hydroxy-6-[1-(3-methoxypr... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
Indoles Metabolite Ethyl 3-methyl-9H-carbazole-9-carboxylate F... 1 1
Putative NP ZINC01795534 Family 2 0
6-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-4,4,6-trimethyl-1,3-diazi... 3 0
methyl-1H-pyrrole NP (z)-2-((3,4-dimethyl-1h-pyrrol-2-yl)methy... 3 0
(4aR,13bS,14aR)-3,4,4a,5,7,8,13,13b,14,14a-decahydro-5,14-etha... 2 0
NP Agn-pc-099dao Family 2 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0
Putative NP ZINC00969838 Family 6 1
Putative NP ZINC00526628 Family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00157948 DCL000862 Clinical Trial Drug LE-300
CFAMM00158095 DNC011016 Investigative Drug 1-tert-butyl-9H-carbazole
CFAMM00157870 DNC003976 Investigative Drug 3-(1-Phenethyl-piperidin-3-yl)-2-phenyl-1H-indole
CFAMM00157672 DNC003250 Investigative Drug 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
CFAMM00158008 DNC011705 Investigative Drug TRYPTAMINE
CFAMM00158103 DNC011654 Investigative Drug PNU-22394
CFAMM00157814 DNC013963 Investigative Drug N-((1H-indol-2-yl)methyl)(phenyl)methanamine
CFAMM00157919 DNC003968 Investigative Drug 2-Phenyl-3-piperidin-4-yl-1H-indole
CFAMM00157933 DNC011618 Investigative Drug 4,9-Dihydro-3H-beta-carboline
CFAMM00158094 DNC011017 Investigative Drug 1-(trifluoromethyl)-9H-carbazole
CFAMM00158143 DNC010997 Investigative Drug 3-methyl-6-(trifluoromethyl)-9H-carbazole
CFAMM00157686 DNC011302 Investigative Drug NSC-78017
CFAMM00157644 DNC004555 Investigative Drug [2-(5-Ethyl-1H-indol-3-yl)-ethyl]-dimethyl-amine
CFAMM00158102 DNC000973 Investigative Drug Mycophenolic acid glucuronide
CFAMM00157784 DNC002827 Investigative Drug Dimethyltryptamine
CFAMM00158065 DNC013387 Investigative Drug 6,11-dihydro-5H-benzo[a]carbazole
CFAMM00157813 DNC013964 Investigative Drug N-((1H-indol-2-yl)methyl)-2-phenylethanamine
CFAMM00157826 DNC003989 Investigative Drug 3-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-indole
CFAMM00157904 DNC006468 Investigative Drug 3-(pyridin-4-yl)-1H-indole
CFAMM00157918 DNC003965 Investigative Drug 2-Phenyl-3-(2-piperidin-1-yl-ethyl)-1H-indole
CFAMM00158093 DNC011014 Investigative Drug 3-tert-butyl-9H-carbazole
CFAMM00157777 DNC013952 Investigative Drug N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine
CFAMM00157790 DNC003992 Investigative Drug 2-Phenyl-3-piperidin-3-yl-1H-indole
CFAMM00157685 DNC011301 Investigative Drug NSC-77833
CFAMM00157897 DNC011020 Investigative Drug 11H-benzo[a]carbazole
CFAMM00158134 DNC011001 Investigative Drug 6-fluoro-2-methyl-9H-carbazole
CFAMM00157812 DNC013965 Investigative Drug N-(1H-Indol-2-ylmethyl)-N-(4-phenylbutyl)amine
CFAMM00157825 DNC003988 Investigative Drug 3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole
CFAMM00157903 DNC006462 Investigative Drug 2-methyl-3-(pyridin-4-yl)-1H-indole
CFAMM00158092 DNC011019 Investigative Drug 2,3,4,11-tetrahydro-1H-benzo[a]carbazole
CFAMM00157710 DNC003990 Investigative Drug 3-(1-Benzyl-piperidin-3-yl)-2-phenyl-1H-indole
CFAMM00158133 DNC011005 Investigative Drug 2-ethyl-9H-carbazole
CFAMM00157860 DNC007095 Investigative Drug N,N-diethyl-2-(1H-indol-3-yl)ethanamine
CFAMM00157887 DNC013962 Investigative Drug N-(1-Methyl-1H-indol-2-ylmethyl)-N-phenylamine
CFAMM00158047 DNC005991 Investigative Drug 2,3-diphenyl-1H-indole
CFAMM00157916 DNC007738 Investigative Drug 4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine
CFAMM00157973 DNC011605 Investigative Drug 9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline
CFAMM00157709 DNC003991 Investigative Drug 3-(1-Methyl-piperidin-2-yl)-2-phenyl-1H-indole
CFAMM00158054 DNC008020 Investigative Drug 3-(1H-indol-3-yl)-N,N-dimethylpropan-1-amine
CFAMM00158132 DNC011004 Investigative Drug 2-tert-butyl-9H-carbazole
CFAMM00158084 DNC002854 Investigative Drug Inhibitor of P38 Kinase
CFAMM00157844 DNC005276 Investigative Drug 2-(1-benzyl-1H-indol-3-yl)-N,N-dimethylethanamine
CFAMM00158152 DNC013655 Investigative Drug 2-(1H-indol-3-yl)-N,N-dimethylethanamine
CFAMM00157944 DNC005672 Investigative Drug 4-(1H-Indol-3-ylmethyl)-phenylamine
CFAMM00157760 DNC004168 Investigative Drug 3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole
CFAMM00158090 DNC005856 Investigative Drug [2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine
CFAMM00158131 DNC011006 Investigative Drug 2-isopropyl-9H-carbazole
CFAMM00157816 DNC013960 Investigative Drug N-(1H-Indol-2-ylmethyl)-N-phenylamine
CFAMM00157972 DNC011609 Investigative Drug TRYPTOLINE
CFAMM00157721 DNC004151 Investigative Drug 3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole
CFAMM00157829 DNC003983 Investigative Drug 3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole
CFAMM00157907 DNC009054 Investigative Drug 3-(1H-indol-3-yl)-N-methyl-3-phenylpropan-1-amine
CFAMM00158096 DNC011013 Investigative Drug 2-tert-butyl-7-(trifluoromethyl)-9H-carbazole
CFAMM00157727 DNC011797 Investigative Drug 3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole
CFAMM00157743 DNC003838 Investigative Drug 3-(1H-Indol-3-yl)-quinoline
CFAMM00157673 DNC011604 Investigative Drug 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole
CFAMM00158009 DNC005277 Investigative Drug [2-(3-Benzyl-indol-1-yl)-ethyl]-dimethyl-amine
CFAMM00157815 DNC013961 Investigative Drug N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine
CFAMM00157892 DPR000097 Investigative Drug Rimcazole
CFAMM00157720 DNC004152 Investigative Drug 3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole
CFAMM00158052 DNC011712 Investigative Drug C-(1H-Indol-3-yl)-methylamine
CFAMM00158082 DNC008237 Investigative Drug 2-(2-(pyrrolidin-1-yl)ethyl)-1H-indole
CFAMM00157828 DNC003980 Investigative Drug 3-(1-Benzyl-piperidin-4-yl)-2-phenyl-1H-indole
CFAMM00157639 DNC011021 Investigative Drug 2-methyl-9H-carbazole
CFAMM00157625 DNC009356 Investigative Drug 3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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