CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD446
Family Name 5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family
No. of Seeds 8 No. of Other Members 38
Family Centroid CFAMM00158206 Functional Category Clinical Trial Drug
Superfamily 5-hydroxytryptamine receptor 2C Ligand Lorcaserin Superfamily
Class Class 48

Cousin Family NamesSeedsMembers
Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
Dopamine reuptake and Noradrenergic re-uptake Inhibitor GSK372... 7 61
Zicronapine family 43 62
Scytalone dehydratase Inhibitor Carpropamid Family 5 2
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 24
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Sodium-dependent dopamine transporter inhibitor [3-(4-chloroph... 1 1
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 1 4
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Sodium-dependent dopamine transporter inhibitor N-[[(1S,3S,4R,... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Kinesin-like protein KIF11 inhibitor 4-(4-chlorophenyl)-4,4-di... 1 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 10
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C inhibitor CHEMBL1353052 family 1 1
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00158206 DCL000872 Clinical Trial Drug Lorcaserin
CFAMM00158164 DNC007034 Investigative Drug (RS/SR)-2-[1-(4-chlorophenyl)ethyl]piperidine
CFAMM00158169 DNC008398 Investigative Drug 6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine
CFAMM00158168 DNC007033 Investigative Drug (RS/SR)-2-[1-(4-chlorophenyl)propyl]piperidine
CFAMM00158175 DNC003956 Investigative Drug SK&F-86466
CFAMM00158167 DNC007032 Investigative Drug (RS/SR)-2-[1-(4-chlorophenyl)butyl]piperidine
CFAMM00158166 DNC007031 Investigative Drug (RS/SR)-2-[1-(4-chlorophenyl)pentyl]piperidine
CFAMM00158165 DNC007030 Investigative Drug (RS/SR)-2-[1-(4-chlorophenyl)hexyl]piperidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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