CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Apoptosis regulator Bcl-2 Inhibitor MCI-186 Family
No. of Seeds 2 No. of Other Members 25
Family Centroid CFAMM00158243 Functional Category Clinical Trial Drug with Human Metabolite
Superfamily Apoptosis regulator Bcl-2 Inhibitor MCI-186 Superfamily
Class Class 1108

Cousin Family NamesSeedsMembers
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Putative cyclooxygenase-3 Inhibitor Dipyrone Family 1 0
Fatty-acid amide hydrolase 1 Inhibitor Phenyl-1,4-bismaleimide... 1 5
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 1 15
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
NADPH oxidase 4 inhibitor SureCN1302618 family 3 0


External ID

Functional Category

Molecule Name

CFAMM00158243 DCL000877 Clinical Trial Drug MCI-186
CFAMM00158234 DNC001118 Investigative Drug Phenazone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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