CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD45
Family Name Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family
No. of Seeds 15 No. of Other Members 81
Family Centroid CFAMM00130771 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
Glucokinase Inhibitor GKA1 Family 2 67
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Coagulation factor X and Neutrophil elastase Inhibitor ZK-8140... 51 17
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
5-hydroxytryptamine receptor 1A ligand 4-chloro-N-[(2S)-2-[4-(... 4 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940907 family 2 21
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940986 family 1 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Cathepsin S and Cathepsin L1 inhibitor AGN-PC-077QOL family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Metabotropic glutamate receptor 5 ligand 2-oxo-N-pyridin-2-yl-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00130822 CHEMBL2392554 Bioactive 4-[[(7R)-9-cyclopentyl-7-ethyl-7-fluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
CFAMM00130798 CHEMBL2171745 Bioactive [3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone
CFAMM00130807 CHEMBL2392544 Bioactive 4-[[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide
CFAMM00130821 CHEMBL2392553 Bioactive 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
CFAMM00130796 CHEMBL2171743 Bioactive [4-[[5-bromo-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
CFAMM00130826 CHEMBL2392558 Bioactive 4-[[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
CFAMM00130841 CHEMBL2178135 Bioactive [4-[[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
CFAMM00130834 CHEMBL2178123 Bioactive [4-[(5-bromo-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
CFAMM00130840 CHEMBL2178134 Bioactive [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
CFAMM00130832 CHEMBL2170016 Bioactive [4-[[5-chloro-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
CFAMM00130824 CHEMBL2392556 Bioactive 4-[[(7S)-9-cyclopentyl-5-methyl-6-oxo-7-prop-2-enyl-7,8-dihydropyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
CFAMM00130845 CHEMBL2178133 Bioactive [2-fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone
CFAMM00130853 DNCL002185 Clinical Trial Drug TAK-960
CFAMM00130765 DCL000067 Clinical Trial Drug BI 2536
CFAMM00130771 DCL000068 Clinical Trial Drug BI 6727

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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