CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name 5-hydroxytryptamine receptor 1A Ligand MN-305 Family
No. of Seeds 12 No. of Other Members 26
Family Centroid CFAMM00158276 Functional Category Clinical Trial Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A Ligand MN-305 Superfamily
Class Class 576

Cousin Family NamesSeedsMembers
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Serotonin re-uptake Inhibitor Paroxetine Family 6 19
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor M2 Ligand Gallamine Triethio... 1 14
Alpha-2 adrenergic receptor Ligand Idazoxan Family 6 26
Acolbifene family 10 115
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 3
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 5 4
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Arachidonate 5-lipoxygenase inhibitor 1-[[(3S)-6-(4-fluorophen... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Beta-lactamase inhibitor CHEMBL1566697 family 1 5


External ID

Functional Category

Molecule Name

CFAMM00158256 CHEMBL2153558 Bioactive 2-(2,6-dimethoxyphenoxy)-N-[[(3R)-5-fluoro-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]ethanamine;hydrochloride
CFAMM00158274 CHEMBL1182155 Bioactive N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine
CFAMM00158254 CHEMBL2153557 Bioactive 2-(2,6-dimethoxyphenoxy)-N-[[(3S)-5-fluoro-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]ethanamine;hydrochloride
CFAMM00158280 CHEMBL289428 Bioactive 2-(2,6-dimethoxyphenoxy)-N-[[(2S,3R)-2-methyl-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]ethanamine
CFAMM00158276 DCL000885 Clinical Trial Drug MN-305
CFAMM00158264 DNC003793 Investigative Drug WB-4101

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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