CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD46
Family Name Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family
No. of Seeds 20 No. of Other Members 43
Family Centroid CFAMM00130910 Functional Category Clinical Trial Drug
Superfamily Mitogen-activated protein kinase 12 Inhibitor Birb 796 Superfamily
Class Class 851

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
DCC-2036 family 2 5
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 50 36
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 1 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Neuropeptide Y receptor type 5 ligand 3-[1-(2-fluorophenyl)pyr... 2 0
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
P2Y purinoceptor 1 inhibitor N-[2-(2-tert-butylphenoxy)pyridin... 2 19
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 1,3-dim... 1 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7
Voltage-dependent calcium channel subunit alpha-2/delta-1 liga... 1 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-073M5F fa... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-073M4E fa... 3 0
Receptor tyrosine-protein kinase erbB-2 and Insulin-like growt... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00130926 CHEMBL318810 Bioactive diaryl urea compound 8
CFAMM00130925 CHEMBL344625 Bioactive BIRB-796 Analog 40
CFAMM00130918 CHEMBL104991 Bioactive SureCN295694
CFAMM00130870 CHEMBL343227 Bioactive BIRB-796 Analog 48
CFAMM00130876 CHEMBL143886 Bioactive SureCN295372
CFAMM00130890 CHEMBL344800 Bioactive BIRB-796 Analog 38
CFAMM00130904 CHEMBL143207 Bioactive SureCN295934
CFAMM00130875 CHEMBL348228 Bioactive SureCN296269
CFAMM00130903 CHEMBL142115 Bioactive SureCN294931
CFAMM00130929 CHEMBL106115 Bioactive SureCN296378
CFAMM00130868 CHEMBL143134 Bioactive diaryl urea compound 9
CFAMM00130902 CHEMBL105248 Bioactive diaryl urea compound 7
CFAMM00130888 CHEMBL420474 Bioactive AGN-PC-074V3T
CFAMM00130928 CHEMBL139991 Bioactive SureCN296227
CFAMM00130894 CHEMBL143141 Bioactive SureCN300495
CFAMM00130908 CHEMBL342523 Bioactive BIRB-796 Analog 39
CFAMM00130921 CHEMBL336001 Bioactive SureCN295577
CFAMM00130880 CHEMBL143373 Bioactive SureCN294966
CFAMM00130893 CHEMBL104749 Bioactive diaryl urea compound 4
CFAMM00130910 DCL000071 Clinical Trial Drug BIRB 796

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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