CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD462
Family Name D(2) dopamine receptor Ligand Pardoprunox Family
No. of Seeds 4 No. of Other Members 81
Family Centroid CFAMM00158772 Functional Category Clinical Trial Drug with Natural Product
Superfamily D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A Binder Superfamily
Class Class 1069

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Calcium-activated potassium channel subunit alpha-1 Ligand Chl... 2 15
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Transforming growth factor-beta Inhibitor ACE-011 Family 1 13
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor SB-13 Family 1 2
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Translocator protein inhibitor 2-(5-bromo-2-oxo-1,3-benzoxazol... 1 0
Translocator protein inhibitor 2-(5-chloro-2-oxo-1,3-benzoxazo... 1 2
Translocator protein inhibitor N-methyl-2-[5-(N-methylanilino)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 12 4
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-087BON family 1 0
2-methylpropyl 2-oxo-1,3-benzoxazole-3-carboxylate NP Isobutyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00158796 CHEMBL405925 Bioactive 3-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,3-benzoxazol-2-one
CFAMM00158818 CHEMBL51251 Bioactive 76875-80-4
CFAMM00158772 DCL000915 Clinical Trial Drug Pardoprunox
CFAMM00158833 DCL000987 Clinical Trial Drug SLV-308

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26851 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 
Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543