CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD465
Family Name D(4) dopamine receptor Ligand PD-165167 Family
No. of Seeds 2 No. of Other Members 96
Family Centroid CFAMM00159187 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily D(4) dopamine receptor Ligand PD-165167 Superfamily
Class Class 615

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Histamine H1 receptor Ligand Tranilast Family 5 125
Substance-P receptor Ligand Ezlopitant Family 10 207
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
DNA-dependent protein kinase catalytic subunit Inhibitor 4-mor... 7 54
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-amino-2h-chromen... 2 3
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Amine oxidase [flavin-containing] B Inhibitor N-isobutyl-2-oxo... 4 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Androgen receptor ligand (6R,7R)-6,7-diethyl-4-(trifluoromethy... 15 20
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor (E)-2... 5 6
Thyroid hormone receptor beta ligand SureCN8892696 family 2 7
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 11 26
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Androgen receptor ligand tert-butyl 4-methyl-2,5-dioxo-1H-chro... 3 0
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-007ZS... 3 3
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 2 0
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Transient receptor potential cation channel subfamily V member... 2 7
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Cathepsin K and Cathepsin B inhibitor N-[1-[[cyano(methyl)amin... 1 1
Estrogen receptor ligand 4-(dodecylamino)-3-[(2-methylphenyl)m... 1 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00159187 DCL000919 Clinical Trial Drug PD-165167
CFAMM00159224 DNC009094 Investigative Drug 2-oxo-N-phenyl-2H-chromene-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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