CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD466
Family Name Mucosal addressin cell adhesion molecule 1 Inhibitor PF-00547659 Family
No. of Seeds 64 No. of Other Members 96
Family Centroid CFAMM00159327 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Mucosal addressin cell adhesion molecule 1 Inhibitor PF-00547659 Superfamily
Class Class 1010

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Dihydroorotate dehydrogenase Inhibitor Antimycin A Family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Transient receptor potential cation channel subfamily V member... 2 29
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
C-X-C chemokine receptor type 2 ligand 3-[[3,4-dioxo-2-(pentan... 6 6
C-X-C chemokine receptor type 2 and C-X-C chemokine receptor t... 9 4
C-X-C chemokine receptor type 2 and C-X-C chemokine receptor t... 1 1
C-X-C chemokine receptor type 2 and C-X-C chemokine receptor t... 3 7
C-X-C chemokine receptor type 2 and C-X-C chemokine receptor t... 2 2
C-X-C chemokine receptor type 2 ligand 3-[[2-[[(1R)-1-(3-fluor... 14 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
C-X-C chemokine receptor type 2 and C-X-C chemokine receptor t... 2 1
C-X-C chemokine receptor type 2 and C-X-C chemokine receptor t... 1 0
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 1 0
N-[3-[(E)-3-(dimethylamino)prop-2-enoyl]-4-hydroxyphenyl]aceta... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00159333 CHEMBL253497 Bioactive 3-[[2-[1-(4-chlorofuran-2-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159396 CHEMBL252851 Bioactive AGN-PC-0CJUTV
CFAMM00159347 CHEMBL246318 Bioactive 3-[[3,4-dioxo-2-[[(1R)-1-(4-pentan-3-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159403 CHEMBL247356 Bioactive 3-[[2-[[(1R)-2,2-dimethyl-1-(4-propan-2-ylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159311 CHEMBL253714 Bioactive 3-[[2-[[(1R)-1-(4-chlorofuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159325 CHEMBL253499 Bioactive 3-[[3,4-dioxo-2-[1-(4-phenylfuran-2-yl)propylamino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159374 CHEMBL401939 Bioactive 3-[[2-[[(1R)-1-(4-bromofuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159340 CHEMBL473145 Bioactive 3-[[3,4-dioxo-2-[[(1R)-3,3,3-trifluoro-1-(furan-2-yl)propyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159265 CHEMBL491135 Bioactive 3-[[2-[[(1S)-1-(4-chlorofuran-2-yl)-2,2,2-trifluoroethyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159278 CHEMBL246731 Bioactive 3-[[2-[[(1R)-1-(4-cyclopentylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159367 CHEMBL216603 Bioactive 3-[[2-[[(R)-cyclopropyl-(5-methylfuran-2-yl)methyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159395 CHEMBL252852 Bioactive 3-[[2-[1-(5-ethylfuran-2-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159410 CHEMBL442799 Bioactive 3-[[3,4-dioxo-2-[[(1S)-2,2,2-trifluoro-1-(4-propan-2-ylfuran-2-yl)ethyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159297 CHEMBL253306 Bioactive (5E)-N,N-dimethyl-5-[[4-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-1-oxo-2,5-dihydro-1,2,5-thiadiazol-3-yl]imino]-6-oxocyclohexa-1,3-diene-1-carboxamide
CFAMM00159310 CHEMBL402965 Bioactive 3-[[2-[[(1R)-1-(3-fluoro-4-methoxyphenyl)-2-methylpropyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159324 CHEMBL253498 Bioactive 3-[[2-[1-(4-bromofuran-2-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159419 CHEMBL491487 Bioactive 3-[[2-[[(1S)-2-fluoro-2-methyl-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159277 CHEMBL245699 Bioactive 3-[[2-[[(1R)-1-(4-ethylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159338 CHEMBL523984 Bioactive 3-[[2-[[(1S)-2,2-difluoro-1-(4-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159366 CHEMBL216602 Bioactive 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)ethyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide
CFAMM00159380 CHEMBL246108 Bioactive 473728-58-4
CFAMM00159290 CHEMBL247150 Bioactive 3-[[2-[[(R)-cyclopropyl-(4-propan-2-ylfuran-2-yl)methyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159303 CHEMBL376414 Bioactive 3-[[2-[[(1R)-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159270 CHEMBL523769 Bioactive 3-[[2-[[(1S)-2,2-difluoro-1-(4-propan-2-ylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159331 CHEMBL403206 Bioactive (5E)-5-[[4-[[(1R)-2,2-dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1-oxo-2,5-dihydro-1,2,5-thiadiazol-3-yl]imino]-N,N-dimethyl-6-oxocyclohexa-1,3-diene-1-carboxamide
CFAMM00159394 CHEMBL515262 Bioactive 3-[[3,4-dioxo-2-[[(1S)-2,2,2-trifluoro-1-(5-methylfuran-2-yl)ethyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159372 CHEMBL246733 Bioactive 3-[[2-[[(1R)-1-(4-cyclohexylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159401 CHEMBL396573 Bioactive 3-[[2-[[(1R)-1-(4-butan-2-ylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159418 CHEMBL516184 Bioactive 3-[[2-[[(1S,2S)-2-fluoro-1-(4-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159302 CHEMBL218115 Bioactive 3-[[2-[[(1R)-1-(furan-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159407 CHEMBL491312 Bioactive 3-[[2-[[(1S)-2,2-difluoro-1-(5-methylfuran-2-yl)but-3-enyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159269 CHEMBL491330 Bioactive 3-[[2-[[(1S)-2,2-difluoro-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159371 CHEMBL254173 Bioactive 3-[[2-[[(1R)-1-(3-fluoro-4-methoxyphenyl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159400 CHEMBL253052 Bioactive 3-[[2-[1-[5-(difluoromethyl)furan-2-yl]propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159262 CHEMBL384889 Bioactive 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide
CFAMM00159275 CHEMBL523645 Bioactive 3-[[3,4-dioxo-2-[[(1S)-2,2,3,3,3-pentafluoro-1-(5-methylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159336 CHEMBL254370 Bioactive 3-[[3,4-dioxo-2-[[(1R)-1-phenylpropyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159350 CHEMBL473959 Bioactive 3-[[3,4-dioxo-2-[[(1S)-2,2,2-trifluoro-1-(furan-2-yl)ethyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159417 CHEMBL394899 Bioactive 3-[[2-[[(1R)-1-(4-tert-butylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159301 CHEMBL254942 Bioactive (5E)-N,N-dimethyl-6-oxo-5-[[1-oxo-4-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]-2,5-dihydro-1,2,5-thiadiazol-3-yl]imino]cyclohexa-1,3-diene-1-carboxamide
CFAMM00159315 CHEMBL247149 Bioactive 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl-1-(4-propan-2-ylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide
CFAMM00159378 CHEMBL246107 Bioactive 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-[4-(4-morpholin-4-ylbutyl)furan-2-yl]propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide
CFAMM00159268 CHEMBL252897 Bioactive 3-[[2-[1-(furan-3-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159399 CHEMBL253051 Bioactive 3-[[2-[1-(5-chlorofuran-2-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159416 CHEMBL472749 Bioactive 3-[[2-[[(1S,2S)-2-fluoro-1-(furan-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159349 CHEMBL404490 Bioactive 3-[[2-[[(1R)-1-(5-chlorofuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159363 CHEMBL404249 Bioactive AGN-PC-034R6D
CFAMM00159430 CHEMBL563855 Bioactive 3-[2-hydroxy-3-(morpholine-4-carbonyl)anilino]-4-[[(1R)-1-phenylpropyl]amino]cyclobut-3-ene-1,2-dione
CFAMM00159274 CHEMBL220182 Bioactive 3-[[2-[[(1R)-1-(1,3-benzodioxol-5-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159300 CHEMBL254943 Bioactive (5E)-5-[[4-[[(1R)-1-(4,5-dimethylfuran-2-yl)-2-methylpropyl]amino]-1-oxo-2,5-dihydro-1,2,5-thiadiazol-3-yl]imino]-N,N-dimethyl-6-oxocyclohexa-1,3-diene-1-carboxamide
CFAMM00159377 CHEMBL246106 Bioactive 3-[[2-[[(1R)-1-(4-butylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159280 CHEMBL245501 Bioactive 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(4-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide
CFAMM00159369 CHEMBL427888 Bioactive 2-hydroxy-3-[[2-[1-[5-(hydroxymethyl)furan-2-yl]propylamino]-3,4-dioxocyclobuten-1-yl]amino]-N,N-dimethylbenzamide
CFAMM00159320 CHEMBL246941 Bioactive 3-[[3,4-dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)ethyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159398 CHEMBL253050 Bioactive 3-[[2-[1-(5-bromofuran-2-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159273 CHEMBL251811 Bioactive 3-[[2-[1-(1-benzofuran-2-yl)propylamino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159286 CHEMBL253705 Bioactive 3-[[3,4-dioxo-2-[1-(4-thiophen-3-ylfuran-2-yl)propylamino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159390 CHEMBL564029 Bioactive 3-[2-hydroxy-3-(pyrrolidine-1-carbonyl)anilino]-4-[[(1R)-1-phenylpropyl]amino]cyclobut-3-ene-1,2-dione
CFAMM00159266 CHEMBL491134 Bioactive 3-[[2-[[(1S)-1-(5-chlorofuran-2-yl)-2,2,2-trifluoroethyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159355 CHEMBL523437 Bioactive 3-[[2-[[(1S)-2,2-difluoro-1-(5-methylfuran-2-yl)butyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159292 CHEMBL523807 Bioactive 3-[[2-[[(1S)-1-(4,5-dichlorofuran-2-yl)-2,2,2-trifluoroethyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
CFAMM00159305 CHEMBL403547 Bioactive (5E)-5-[[4-[[(1R)-1-(furan-2-yl)-2,2-dimethylpropyl]amino]-1-oxo-2,5-dihydro-1,2,5-thiadiazol-3-yl]imino]-N,N-dimethyl-6-oxocyclohexa-1,3-diene-1-carboxamide
CFAMM00159382 CHEMBL556862 Bioactive SureCN13590831
CFAMM00159327 DCL000924 Clinical Trial Drug PF-00547659

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26200 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543