CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD468
Family Name 5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00159458 Functional Category Clinical Trial Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 2A and Serine/threonine-protein kinase PLK1 Binder Superfamily
Class Class 906

Cousin Family NamesSeedsMembers
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A4C Family 3 18
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 11
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-butoxy... 1 1
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Histamine H1 receptor and Arachidonate 5-lipoxygenase Ligand N... 5 6
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Histamine H3 receptor ligand SureCN6071181 family 2 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 6 0
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BAX family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00159458 DCL000930 Clinical Trial Drug Pimavanserin
CFAMM00159438 DNC010407 Investigative Drug 4-fluorophenyl 4-butoxybenzylcarbamate
CFAMM00159437 DNC010404 Investigative Drug 2,4-difluorophenyl 4-butoxybenzylcarbamate
CFAMM00159436 DNC010405 Investigative Drug 2-fluorophenyl 4-butoxybenzylcarbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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