CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD476
Family Name Cytochrome P450 26A1 Inhibitor Rambazole Family
No. of Seeds 7 No. of Other Members 77
Family Centroid CFAMM00159811 Functional Category Clinical Trial Drug
Superfamily Cytochrome P450 26A1 Inhibitor Rambazole Superfamily
Class Class 1124

Cousin Family NamesSeedsMembers
Fumarate reductase flavoprotein subunit Inhibitor Thiabendazol... 3 20
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine recept... 7 15
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase Inhibitor 1-benzothiazol-2-yl-3-phenethy... 2 19
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Metabotropic glutamate receptor 1 ligand N-cyclohexyl-7-[[2-me... 2 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand N-[5-(4,5-dihydro-[1]ben... 8 9
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 1 1
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Histamine H3 receptor ligand 5-(3-bromophenyl)-2-[2-(1H-imidaz... 2 2
Bombesin receptor subtype-3 ligand AGN-PC-07ZCL7 family 1 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00FW8Y family 1 1
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
D(2) dopamine receptor ligand 7-[(1-methylpyrazol-4-yl)methyl]... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 3 2
Mitogen-activated protein kinase 14 inhibitor 6-[2-(3-chloroph... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00159750 CHEMBL517438 Bioactive N-[4-[(1R,2R)-2-(dimethylamino)-1-imidazol-1-ylpropyl]phenyl]-1,3-benzothiazol-2-amine
CFAMM00159790 CHEMBL224305 Bioactive (R)-Talarozole
CFAMM00159735 CHEMBL256925 Bioactive 6-(5-phenyl-1H-imidazol-4-yl)-N-propan-2-yl-1,3-benzothiazol-2-amine
CFAMM00159803 CHEMBL255469 Bioactive N-[(2S)-butan-2-yl]-6-[5-(2-fluorophenyl)-1H-imidazol-4-yl]-1,3-benzothiazol-2-amine
CFAMM00159809 CHEMBL403942 Bioactive 6-[5-(2-fluorophenyl)-1H-imidazol-4-yl]-N-propan-2-yl-1,3-benzothiazol-2-amine
CFAMM00159833 CHEMBL439238 Bioactive N-[(2R)-butan-2-yl]-6-[5-(2-fluorophenyl)-1H-imidazol-4-yl]-1,3-benzothiazol-2-amine
CFAMM00159811 DCL000950 Clinical Trial Drug Rambazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543