CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD48
Family Name Farnesyltransferase beta subunit, putative Inhibitor BMS214662 Family
No. of Seeds 11 No. of Other Members 65
Family Centroid CFAMM00131241 Functional Category Clinical Trial Drug
Superfamily Farnesyltransferase beta subunit, putative Inhibitor BMS214662 Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Motilin receptor and Growth hormone secretagogue receptor type... 2 2
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 2 0
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
A disintegrin and metalloproteinase with thrombospondin motifs... 1 0
Histone deacetylase 1 inhibitor (7S)-7-(5-naphthalen-2-yl-1H-i... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00131230 CHEMBL331640 Bioactive SureCN3499974
CFAMM00131245 CHEMBL118181 Bioactive SureCN3499338
CFAMM00131194 CHEMBL360917 Bioactive AGN-PC-01RE11
CFAMM00131171 CHEMBL118616 Bioactive SureCN3501484
CFAMM00131193 CHEMBL183499 Bioactive AGN-PC-01LXC7
CFAMM00131222 CHEMBL1201849 Bioactive N-[(3R)-6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-N-(thiophen-3-ylmethyl)benzenesulfonamide
CFAMM00131191 CHEMBL421235 Bioactive SureCN3500801
CFAMM00131205 CHEMBL118669 Bioactive SureCN3499278
CFAMM00131233 CHEMBL192344 Bioactive SureCN134854
CFAMM00131196 CHEMBL1169541 Bioactive N-[(3S)-6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-N-(thiophen-3-ylmethyl)benzenesulfonamide
CFAMM00131241 DCL000073 Clinical Trial Drug BMS214662

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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