CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD481
Family Name Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor Family
No. of Seeds 6 No. of Other Members 39
Family Centroid CFAMM00160016 Functional Category Clinical Trial Drug
Superfamily Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor Superfamily
Class Class 1128

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Triprolidine Family 19 316
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Coagulation factor X Inhibitor M55113 Family 1 8
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Plasminogen and Urokinase-type plasminogen activator Inhibitor... 3 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Neuropeptide Y receptor type 5 ligand 2-[4-(benzenesulfonamido... 2 27
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Disintegrin and metalloproteinase domain-containing protein 17... 5 9
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 3 2
Rho-associated protein kinase 2 and Ribosomal protein S6 kinas... 6 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
P2X purinoceptor 7 inhibitor AGN-PC-015BSR family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00159992 CHEMBL406821 Bioactive (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
CFAMM00159979 CHEMBL1082440 Bioactive Kinome_3845
CFAMM00160016 DCL000959 Clinical Trial Drug Rho-kinase inhibitor
CFAMM00160010 DNC008014 Investigative Drug N-(2-aminoethyl)isoquinoline-5-sulfonamide
CFAMM00160023 DNC014869 Investigative Drug 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline
CFAMM00159994 DNC000640 Investigative Drug Fasudil

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27744 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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