CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD485
Family Name 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Ligand Sarizotan Family
No. of Seeds 9 No. of Other Members 115
Family Centroid CFAMM00160217 Functional Category Clinical Trial Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Ligand Sarizotan Superfamily
Class Class 1129

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
SB1518 family 7 103
Apricoxib family 8 77
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
Prostaglandin D2 receptor 2 ligand 2-[4-chloro-2-[2-(4-propylp... 2 13
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 4 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 34 23
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 2
Beta-secretase 1 inhibitor CHEMBL2152919 family 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 2,... 1 8
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYD family 3 7
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Renin inhibitor SureCN6044003 family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 5 13
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Thyroid hormone receptor beta and Cytochrome P450 2C19 ligand ... 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 7 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-04XS1Y f... 1 4
Nischarin inhibitor SureCN7810370 family 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Beta-3 adrenergic receptor ligand N-[2-hydroxy-5-[(1R)-1-hydro... 2 1
Platelet-activating factor receptor ligand SureCN9575051 family 1 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Transient receptor potential cation channel subfamily V member... 3 2
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Acetylcholinesterase inhibitor 2-methoxy-6-[5-(6-methoxy-1-met... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Reverse transcriptase/RNaseH inhibitor 6Et-7,9-diMe-PBOA-5thio... 1 1
P2X purinoceptor 7 inhibitor 3-[1-[4-(3-nitrophenyl)phenoxy]-4... 1 1
Small conductance calcium-activated potassium channel protein ... 1 1
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[(3R)... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-0A9UZU fa... 3 0
Butyrylcholinesterase and Muscarinic acetylcholine receptor M2... 1 0
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
NP (2r,3r,4s,5r)-2-(acetoxymethyl)-6-(quinolin-8-yloxy)tetrahy... 2 1
dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00160248 CHEMBL136563 Bioactive (3E)-3-(5-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)-N-(2-pyridin-2-yloxyethyl)propan-1-amine
CFAMM00160265 CHEMBL220808 Bioactive Sarizotan
CFAMM00160314 CHEMBL359725 Bioactive 3-N-(2-phenoxyethyl)-5-N-[(1S)-1-phenylethyl]pyridine-3,5-diamine
CFAMM00160217 DCL000973 Clinical Trial Drug Sarizotan
CFAMM00160204 DNC006913 Investigative Drug 2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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