CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name 72 kDa type IV collagenase and Interstitial collagenase Inhibitor Marimastat Family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00126776 Functional Category Clinical Trial Drug
Superfamily 72 kDa type IV collagenase and Interstitial collagenase Inhibitor Marimastat Superfamily
Class Class 646

Cousin Family NamesSeedsMembers
Bacterial outer membrane inhibitor polymyxin Colistin Family 26 160
Peptide deformylase, mitochondrial Inhibitor Actinonin Family 2 12
Interstitial collagenase and Stromelysin-1 inhibitor (9S,12R,1... 1 0


External ID

Functional Category

Molecule Name

CFAMM00126773 CHEMBL48258 Bioactive (9S,12R,13S)-13-N-hydroxy-9-N-methyl-12-(2-methylpropyl)-3,11-dioxo-1-oxa-4,10-diazacyclotridecane-9,13-dicarboxamide
CFAMM00126771 CHEMBL115189 Bioactive (2R,3S)-N-[3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide
CFAMM00126779 CHEMBL357195 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-3-methoxy-2-(2-methylpropyl)butanediamide
CFAMM00126778 CHEMBL433314 Bioactive (2R,3R)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-3-(hydroxymethyl)-2-(2-methylpropyl)butanediamide
CFAMM00126777 CHEMBL70398 Bioactive (2S,3R)-N,2-dihydroxy-N'-[(2R)-4-methyl-1-(methylamino)-1-oxopentan-2-yl]-3-(2-methylpropyl)butanediamide
CFAMM00126776 DCL000005 Clinical Trial Drug Marimastat

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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