CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD506
Family Name Substance-P receptor Ligand TAK-637 Family
No. of Seeds 18 No. of Other Members 63
Family Centroid CFAMM00161242 Functional Category Clinical Trial Drug
Superfamily Substance-P receptor Ligand TAK-637 Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
HIV protease Inhibitor Saquinavir Family 64 428
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Amg 423 family 7 47
Setipiprant family 5 118
ABC294640 family 5 75
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
C-C chemokine receptor type 5 Ligand Sch 351125 Family 6 29
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
PF-4136309 family 16 27
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
M-phase inducer phosphatase 3 Inhibitor NSC-663284 Family 1 12
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
B1 bradykinin receptor ligand ELN-441958 family 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Cathepsin K inhibitor SureCN2155973 family 3 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
C-C chemokine receptor type 5 and Muscarinic acetylcholine rec... 3 0
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histamine H3 receptor ligand SureCN1857507 family 1 4
Renin inhibitor (3R,4S)-N-cyclopropyl-N-[[2-(3-methoxypropyl)q... 2 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-cyanoph... 6 6
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 3 3
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Cathepsin S inhibitor N-[(S)-[1-(1-cyanocyclopropyl)triazol-4-... 1 0
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Beta-secretase 1 inhibitor N-[3-[(4R,5R,6S)-2-amino-5-fluoro-4... 4 11
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 2 17
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Glutamate receptor 1 and Glutamate receptor 2 ligand cp-465022... 1 6
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (7S)-... 2 19
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 10 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
C-C chemokine receptor type 5 ligand 5-[(3aR,6aS)-2-[2-[1-(4,4... 4 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R9GP family 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 6-(3... 1 3
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
Acetylcholinesterase inhibitor CHEMBL267591 family 5 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
C-C chemokine receptor type 3 ligand AGN-PC-046Y2D family 1 1
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Histamine H3 receptor ligand Conessine analogue, 12e family 1 6
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
Muscarinic acetylcholine receptor M2 ligand 2-[3-[(E)-[1-[6-[4... 5 0
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 1
N-[2-(1-oxidopyridin-1-ium-2-yl)ethyl]-N-phenylacetamide NP 2-... 1 2
Putative NP ZINC03999850 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00161246 CHEMBL1946016 Bioactive N,N-diethyl-4-[[1-[(4-fluorophenyl)methyl]piperidin-4-ylidene]-pyridin-2-ylmethyl]benzamide
CFAMM00161175 CHEMBL415705 Bioactive N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N,7-dimethyl-8-oxo-5-phenyl-1,7-naphthyridine-6-carboxamide
CFAMM00161168 CHEMBL128586 Bioactive 7-(3,5-BIS-TRIFLUOROMETHYL-BENZYL)-9-METHYL-5-P-TOLYL-8,9,10,11-TETRAHYDRO-7H-1,7,11A-TRIAZA-CYCLOOCTA[B]NAPHTHALENE-6,12-DIONE (ATROPISOMERIC MIX)
CFAMM00161229 CHEMBL265986 Bioactive AGN-PC-0760AB
CFAMM00161160 CHEMBL129354 Bioactive (9R)-7-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-methyl-5-(4-methylphenyl)-9,10-dihydro-8H-[1,4]diazepino[2,1-g][1,7]naphthyridine-6,12-dione
CFAMM00161248 CHEMBL107482 Bioactive N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-fluorophenyl)-N,7-dimethyl-8-oxo-1,7-naphthyridine-6-carboxamide
CFAMM00161204 CHEMBL336589 Bioactive 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (S)-[(S)-1-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL]-METHYL-AMIDE (ENANTIOMERIC MIX)
CFAMM00161171 CHEMBL317870 Bioactive AGN-PC-00F9CC
CFAMM00161166 CHEMBL1939754 Bioactive N-ethyl-N-methyl-4-[(R)-pyridin-2-yl-[4-(pyridin-2-ylmethyl)piperazin-1-yl]methyl]benzamide
CFAMM00161257 CHEMBL106904 Bioactive SureCN7855109
CFAMM00161261 CHEMBL128369 Bioactive (9S)-7-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-methyl-5-(4-methylphenyl)-9,10-dihydro-8H-[1,4]diazepino[2,1-g][1,7]naphthyridine-6,12-dione
CFAMM00161194 CHEMBL340931 Bioactive AGN-PC-00GFC9
CFAMM00161225 CHEMBL130834 Bioactive 7-(3,5-BIS-TRIFLUOROMETHYL-BENZYL)-5-P-TOLYL-8,9,10,11-TETRAHYDRO-7H-1,7,11A-TRIAZA-CYCLOOCTA[B]NAPHTHALENE-6,12-DIONE (ATROPISOMERIC MIX)
CFAMM00161219 CHEMBL340732 Bioactive CHEMBL340732
CFAMM00161178 CHEMBL128384 Bioactive 7-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-methylphenyl)-9,10-dihydro-8H-[1,4]diazepino[2,1-g][1,7]naphthyridine-6,12-dione
CFAMM00161232 CHEMBL104301 Bioactive N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-fluorophenyl)-7-methyl-8-oxo-1,7-naphthyridine-6-carboxamide
CFAMM00161242 DCL001011 Clinical Trial Drug TAK-637
CFAMM00161162 DNC004528 Investigative Drug 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (S)-[( R)-1-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL]-METHYL-AMIDE (ENANTIOMERIC MIX)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22645 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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