CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD507
Family Name Tumor necrosis factor Inhibitor Talactoferrin Alfa Family
No. of Seeds 26 No. of Other Members 131
Family Centroid CFAMM00161385 Functional Category Clinical Trial Drug
Superfamily Tumor necrosis factor Inhibitor Talactoferrin Alfa Superfamily
Class Class 961

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Neuromedin-K receptor Ligand Osanetant Family 38 192
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 8 13
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Sodium-dependent dopamine transporter and Transporter inhibito... 4 3
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Substance-K receptor ligand SureCN3083325 family 4 0
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Mu-type opioid receptor ligand CHEMBL303404 family 1 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 3 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
C-C chemokine receptor type 3 ligand AGN-PC-075CFD family 2 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Putative Bioactive [3-[benzoyl(hydroxy)amino]-1-(3,4-dichlorop... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00161360 CHEMBL612078 Bioactive 2-(3,4-dichlorophenyl)-1-[(2S)-2-(1-methylpyrrolidin-2-yl)piperidin-1-yl]ethanone
CFAMM00161325 CHEMBL130272 Bioactive AGN-PC-002MQS
CFAMM00161386 CHEMBL62663 Bioactive SureCN10417791
CFAMM00161418 CHEMBL128444 Bioactive BRL 52537
CFAMM00161277 CHEMBL1095519 Bioactive methyl (3R)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(1R)-1-pyrrolidin-1-ylethyl]piperazine-1-carboxylate
CFAMM00161338 CHEMBL2114291 Bioactive 1-[(3S)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(1S)-1-pyrrolidin-1-ylethyl]piperazin-1-yl]propan-1-one
CFAMM00161378 CHEMBL63810 Bioactive SureCN10416654
CFAMM00161390 CHEMBL62879 Bioactive SureCN8221866
CFAMM00161302 CHEMBL71294 Bioactive BRL-52537
CFAMM00161356 CHEMBL56653 Bioactive Ici-197067
CFAMM00161421 CHEMBL65511 Bioactive CHEBI:129514
CFAMM00161349 CHEMBL1094879 Bioactive methyl (3S)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(1S)-1-pyrrolidin-1-ylethyl]piperazine-1-carboxylate
CFAMM00161362 CHEMBL2115273 Bioactive 1-[(3R)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(1R)-1-pyrrolidin-1-ylethyl]piperazin-1-yl]propan-1-one
CFAMM00161368 CHEMBL277863 Bioactive methyl (3R)-4-[2-(3,4-dichlorophenyl)acetyl]-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate
CFAMM00161413 CHEMBL148083 Bioactive SureCN9734456
CFAMM00161340 CHEMBL2114295 Bioactive methyl (3S)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(1R)-1-pyrrolidin-1-ylethyl]piperazine-1-carboxylate
CFAMM00161367 CHEMBL482811 Bioactive U-50488H
CFAMM00161385 DCL001012 Clinical Trial Drug Talactoferrin Alfa
CFAMM00161409 DNC001481 Investigative Drug U50,488H
CFAMM00161308 DNC004906 Investigative Drug ICI-199441
CFAMM00161408 DNC001482 Investigative Drug U-50488H
CFAMM00161374 DNC000350 Investigative Drug BRL 52537 hydrochloride
CFAMM00161279 DNC013742 Investigative Drug (+/-)-TRANS-U-50488 METHANESULFONATE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27058 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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