CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD510
Family Name Tumor necrosis factor Inhibitor Tgaac-94 Family
No. of Seeds 6 No. of Other Members 107
Family Centroid CFAMM00161585 Functional Category Clinical Trial Drug with Natural Product
Superfamily Tumor necrosis factor Inhibitor Tgaac-94 Superfamily
Class Class 1145

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Calcium-activated potassium channel subunit alpha-1 Ligand Chl... 2 15
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 6 Ligand SB-357134 Family 13 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Pyruvate kinase PKLR and Pyruvate kinase PKM inhibitor AGN-PC-... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 15 14
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
5-hydroxytryptamine receptor 6 ligand N-(3,5-dichlorophenyl)-4... 7 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Capsid scaffolding protein inhibitor AC1LAC6N family 2 1
Nischarin inhibitor SureCN7818902 family 2 12
5-hydroxytryptamine receptor 6 ligand 1-(4-methoxy-3-piperazin... 6 3
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BRZ7B family 9 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
Renin inhibitor (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-o... 2 0
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00161585 DCL001018 Clinical Trial Drug TgAAC-94
CFAMM00161482 DNC004170 Investigative Drug RWJ-38063
CFAMM00161622 DNC004165 Investigative Drug RWJ-69736
CFAMM00161503 DNC004908 Investigative Drug 1-(2-Methoxy-phenyl)-piperazine
CFAMM00161586 DNC004942 Investigative Drug RS-100329
CFAMM00161557 DNC004935 Investigative Drug Ro-700004

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23724 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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