CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD512
Family Name D(3) dopamine receptor Ligand U-99194A Family
No. of Seeds 7 No. of Other Members 33
Family Centroid CFAMM00161671 Functional Category Clinical Trial Drug with Natural Product
Superfamily D(3) dopamine receptor Ligand U-99194A Superfamily
Class Class 38

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand DA-5018 Family 14 73
Translocator protein Inhibitor Dextofisopam Family 3 250
Substance-P receptor Ligand Ezlopitant Family 10 207
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Vernakalant family 1 1
Ivabradine family 1 11
Oxi4503 family 4 27
Dapoxetine family 3 40
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
Platelet-activating factor receptor Ligand L-652731 Family 5 116
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Coagulation factor VII and Coagulation factor X Inhibitor 4-(4... 2 12
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Aromatase Inhibitor 2,3,4-trimethoxy-4'-amino-trans-stilbene F... 9 14
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tubulin beta chain Inhibitor Colchinol Family 3 109
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Amine oxidase [flavin-containing] A Inhibitor 2-(4-methoxyphen... 2 7
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Transient receptor potential cation channel subfamily V member... 3 18
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Transient receptor potential cation channel subfamily V member... 14 7
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 11 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Squalene monooxygenase inhibitor 2-[[3-[[[(E)-6,6-dimethylhept... 4 4
High affinity choline transporter 1 inhibitor 1-[4-(3,4,5-trim... 2 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
5-hydroxytryptamine receptor 1A ligand (Z)-1-diazonio-3-[[7-(d... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 1
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
Metabotropic glutamate receptor 2 ligand 4-(3,4-dimethoxypheny... 1 0
Endothelin-converting enzyme 1 inhibitor [[(2S)-5-(2,4-difluor... 1 0
D(2) dopamine receptor ligand AGN-PC-00PT7Q family 2 1
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Indoles and Derivatives Metabolite Lenticin Family 1 0
3-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)amino... 3 0
Putative NP ZINC04061066 Family 18 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
NP N-(3,4-dimethoxyphenethyl)-2-(2-(hydroxymethyl)-5-methoxy-4... 1 0
Putative NP ZINC19322380 Family 2 2
Putative NP ZINC13119705 Family 3 0
NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0
NP (e)-3-(3,4-dimethoxyphenyl)-1-((4as,8as)-4a-hydroxyoctahydr... 2 0
Putative NP ZINC04287792 Family 2 0
Putative NP ZINC01322649 Family 2 0
Putative NP ZINC00050501 Family 6 4
3-(2,3-dihydro-1,4-benzodioxin-6-yl)chromene-4-thione NP 3-(2,... 1 0
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00161641 CHEMBL128717 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N,N-dipropylbutan-2-amine
CFAMM00161648 CHEMBL1256838 Bioactive U-99194A maleate
CFAMM00161646 CHEMBL341003 Bioactive 1-[4-methoxy-3-(2-phenylethoxy)phenyl]-N,N-dipropylpentan-2-amine
CFAMM00161671 DCL001028 Clinical Trial Drug U-99194A
CFAMM00161637 DNC001409 Investigative Drug TAM-67

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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