CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD514
Family Name Substance-P receptor Ligand Vestipitant Family
No. of Seeds 14 No. of Other Members 137
Family Centroid CFAMM00161827 Functional Category Clinical Trial Drug with Natural Product
Superfamily Substance-P receptor Ligand Vestipitant Superfamily
Class Class 1148

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Bethanidine Family 2 22
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Bavisant family 9 65
Zicronapine family 43 62
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Glycogen synthase kinase-3 Inhibitor NP12 Family 3 5
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-[1-(4-isobut... 1 7
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 11 6
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 5 20
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
Cellular tumor antigen p53 and Retinal dehydrogenase 1 inhibit... 1 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
C-C chemokine receptor type 3 ligand 1-(2,3-dimethyl-3a,7a-dih... 4 0
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 5
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 1
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
Tryptase alpha/beta-1 and Trypsin-1 inhibitor AGN-PC-074JFM fa... 3 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent noradrenaline transporter and Muscarinic acet... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
Prostaglandin E synthase inhibitor AGN-PC-09QIZR family 1 1
C-C chemokine receptor type 3 ligand 4-(benzenesulfonyl)-N-[(1... 1 1
Histamine H3 receptor ligand (2S)-N-(2,3-dihydro-1H-inden-2-yl... 2 1
Melanin-concentrating hormone receptor 1 ligand 1-[[4-(4-fluor... 2 10
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 7
Cannabinoid receptor 1 ligand AGN-PC-078YV8 family 1 2
Histamine H3 receptor ligand AGN-PC-077LOO family 1 4
Acetylcholinesterase inhibitor (E)-1-N'-benzyl-1-N-[2-(1-benzy... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00161751 CHEMBL1257106 Bioactive Amperozide hydrochloride
CFAMM00161715 CHEMBL490755 Bioactive AGN-PC-071G9E
CFAMM00161847 CHEMBL591074 Bioactive [6-[3,5-bis(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-[(2S)-2-(4-fluoro-2-methylphenyl)piperazin-1-yl]methanone
CFAMM00161840 CHEMBL205437 Bioactive (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE
CFAMM00161846 CHEMBL591075 Bioactive [2-[3,5-bis(trifluoromethyl)phenyl]piperidin-1-yl]-[(2S)-2-(4-fluoro-2-methylphenyl)piperazin-1-yl]methanone
CFAMM00161698 CHEMBL523156 Bioactive (2R)-N-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide
CFAMM00161825 CHEMBL489924 Bioactive acetic acid;(2R)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide
CFAMM00161837 CHEMBL492117 Bioactive acetic acid;(2S)-N-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide
CFAMM00161740 CHEMBL589371 Bioactive (2S)-N-[1-[3,5-bis(trifluoromethyl)phenyl]cyclopropyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide
CFAMM00161771 CHEMBL490926 Bioactive (2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide
CFAMM00161827 DCL001035 Clinical Trial Drug Vestipitant
CFAMM00161803 DNC010648 Investigative Drug AMPEROZIDE
CFAMM00161726 DNC010620 Investigative Drug 4-benzhydryl-N-butylpiperazine-1-carboxamide
CFAMM00161777 DNC010619 Investigative Drug 4-benzhydryl-N-cyclohexylpiperazine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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