CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD518
Family Name Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-894 Family
No. of Seeds 23 No. of Other Members 63
Family Centroid CFAMM00162099 Functional Category Clinical Trial Drug
Superfamily Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-894 Superfamily
Class Class 1150

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 7 Ligand 2-[1-(2-chloro-phenyl)-1... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Acetylcholine receptor subunit delta and Neuronal acetylcholin... 3 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00162166 CHEMBL218544 Bioactive (1S,6R)-7-(6-chloro-5-methylpyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162117 CHEMBL219194 Bioactive (1S,6R)-4-(5,6-dichloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162123 CHEMBL468065 Bioactive (1R,6S)-7-(6-chloro-5-methylpyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162137 CHEMBL220411 Bioactive (1S,6R)-7-(6-chloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162096 CHEMBL210548 Bioactive 1-(5-chloropyridin-3-yl)-1,5-diazocane
CFAMM00162136 CHEMBL484831 Bioactive (3aS,6aR)-5-(6-chloropyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole;hydrochloride
CFAMM00162151 CHEMBL373776 Bioactive (1S,6R)-4-(6-chloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162144 CHEMBL245259 Bioactive AGN-PC-015BP3
CFAMM00162121 CHEMBL494773 Bioactive SureCN651804
CFAMM00162101 CHEMBL451075 Bioactive (1R,6S)-7-(6-chloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162163 CHEMBL450667 Bioactive (1R,6S)-7-(5,6-dichloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162128 CHEMBL245243 Bioactive AGN-PC-00PBNR
CFAMM00162156 CHEMBL219302 Bioactive (1S,6R)-7-(5,6-dichloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162107 CHEMBL218191 Bioactive (1S,6R)-4-(6-chloro-5-methylpyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162182 CHEMBL208784 Bioactive AGN-PC-00AJCZ
CFAMM00162094 CHEMBL388684 Bioactive AGN-PC-015BPD
CFAMM00162134 CHEMBL481977 Bioactive (1R,6S)-4-(6-chloro-5-methylpyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162168 CHEMBL479614 Bioactive (1R,6S)-4-(6-chloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162119 CHEMBL388699 Bioactive AGN-PC-015BFD
CFAMM00162125 CHEMBL506353 Bioactive (1R,6S)-4-(5,6-dichloropyridin-3-yl)-4,7-diazabicyclo[4.2.0]octane
CFAMM00162105 CHEMBL462846 Bioactive AGN-PC-077S0G
CFAMM00162111 CHEMBL398004 Bioactive AGN-PC-015BP0
CFAMM00162099 DCL001044 Clinical Trial Drug ABT-894

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543