CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD540
Family Name Histone deacetylase 1 Inhibitor AN-9 Family
No. of Seeds 31 No. of Other Members 282
Family Centroid CFAMM00163505 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Histone deacetylase 1 Inhibitor AN-9 Superfamily
Class Class 1161

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 18
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Glutamate receptor ionotropic, NMDA 1 Ligand Dcka, 5,7-dichlor... 2 7
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Urokinase-type plasminogen activator Inhibitor 1-[4-(2-oxo-2-p... 1 3
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Extracellular calcium-sensing receptor Ligand 3-phenethyl-2-ph... 3 137
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Transient receptor potential cation channel subfamily V member... 6 33
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Telomerase reverse transcriptase Inhibitor 2,7-dinitroantraqui... 3 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Bifunctional epoxide hydrolase 2 Inhibitor 4-(3-adamantan-1-yl... 3 12
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Adenosine receptor A2a Ligand 1-amino-4-chloroanthracene-9,10-... 1 3
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Histone deacetylase 2 Inhibitor N-(4-amino-4'-bromobiphenyl-3-... 1 1
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Dihydroorotate dehydrogenase Inhibitor N-(4-bromo-2-methylphen... 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Vasopressin V1a receptor ligand AGN-PC-074VSA family 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 5 13
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-eth... 7 3
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Cannabinoid receptor 2 ligand AGN-PC-087MPO family 7 21
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 6 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 2
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Sphingosine 1-phosphate receptor 1 ligand 7-(2-hydroxyethyl)-1... 2 10
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Mitogen-activated protein kinase 14 inhibitor N-[3-[(11-oxo-5,... 2 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
Mitogen-activated protein kinase 14 inhibitor ethyl 2-[[3-(2,4... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-(3-benzamido-4... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-(2,4-difluoroa... 6 0
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Cannabinoid receptor 2 ligand AGN-PC-046LZ0 family 1 0
Histone deacetylase 1 inhibitor SureCN3642893 family 10 23
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand Su... 1 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 1
Caspase-3 and Caspase-7 inhibitor AGN-PC-00BUR6 family 2 1
Caspase-3 inhibitor Benzamide, 3-nitro-N-(1,2,3,4-tetrahydro-1... 2 3
Caspase-3 inhibitor SureCN12857739 family 1 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Cytochrome P450 2C19 and 3-hydroxyacyl-CoA dehydrogenase type-... 1 5
Progesterone receptor ligand AGN-PC-00PB7N family 2 1
Acenes Metabolite C.I. Pigment Red 149 Family 1 0
Quinolines and Derivatives Metabolite 4,11-Dichloro-5,12-dihyd... 1 0
1-benzoyl-6-chloro-2H-naphtho[1,2,3-de]quinoline-2,7(3H)-dione... 1 2
6-methyl-3-[(6-methyl-2-oxido-4-oxo-1H-quinolin-3-yl)methyl]-4... 1 1
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
1H-quinolin-4-one NP 4-(6-bromo-4-hydroxy-2-methylquinolin-3-y... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00163505 DCL001103 Clinical Trial Drug AN-9
CFAMM00163616 DNC009262 Investigative Drug 2,7-Bis[2-(butylamino)acetamido]anthraquinone
CFAMM00163794 DNC009244 Investigative Drug 2,7-Bis(propionamido)anthraquinone
CFAMM00163514 DNC009254 Investigative Drug 2,7-Bis[3-(propylamino)propionamido]anthraquinone
CFAMM00163585 DNC006429 Investigative Drug 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione
CFAMM00163683 DNC009239 Investigative Drug 2,7-Bis(cyclopropanecarbonamido)anthraquinone
CFAMM00163793 DNC009245 Investigative Drug 2,7-Bis(acetamido)anthraquinone
CFAMM00163568 DNC009237 Investigative Drug 2,7-Bis(cyclohexanecarbonamido)anthraquinone
CFAMM00163513 DNC009257 Investigative Drug 2,7-Bis[2-(isopropylamino)acetamido]anthraquinone
CFAMM00163682 DNC009238 Investigative Drug 2,7-Bis(cyclopentanecarbonamido)anthraquinone
CFAMM00163799 DNC009242 Investigative Drug 2,7-Bis(benzoamido)anthraquinone
CFAMM00163792 DNC009248 Investigative Drug 2,7-Bis(3-chloropropionamido)anthraquinone
CFAMM00163739 DNC005941 Investigative Drug (R)-sirtinol
CFAMM00163512 DNC009256 Investigative Drug 2,7-Bis[2-(isobutylamino)acetamido]anthraquinone
CFAMM00163798 DNC009243 Investigative Drug 2,7-Bis(butyramido)anthraquinone
CFAMM00163576 DNC009263 Investigative Drug 2,7-Bis(chloroacetamido)anthraquinone
CFAMM00163745 DNC010369 Investigative Drug 1-aminoanthracene-9,10-dione
CFAMM00163751 DNC010365 Investigative Drug 1,4-diaminoanthracene-9,10-dione
CFAMM00163511 DNC009259 Investigative Drug 2,7-Bis[2-(propylamino)acetamido]anthraquinone
CFAMM00163797 DNC009240 Investigative Drug 2,7-Bis(phenylpropionamido)anthraquinone
CFAMM00163517 DNC009253 Investigative Drug 2,7-Bis[3-(ethylamino)propionamido]anthraquinone
CFAMM00163635 DNC005940 Investigative Drug (S)-sirtinol
CFAMM00163737 DNC005943 Investigative Drug meta-sirtinol
CFAMM00163796 DNC009241 Investigative Drug 2,7-Bis(phenylacetamido)anthraquinone
CFAMM00163510 DNC009258 Investigative Drug 2,7-Bis[2-(ethylamino)acetamido]anthraquinone
CFAMM00163516 DNC009252 Investigative Drug 2,7-Bis[2-(diethylamino)acetamido]anthraquinone
CFAMM00163617 DNC009260 Investigative Drug 2,7-Bis[2-(dimethylamino)acetamido]anthraquinone
CFAMM00163632 DNC010370 Investigative Drug 2-amino-3-(m-tolylamino)naphthalene-1,4-dione
CFAMM00163580 DNC000195 Investigative Drug Ametantrone
CFAMM00163795 DNC009246 Investigative Drug 2,7-Bis(4-chlorobutyramido)anthraquinone
CFAMM00163515 DNC009255 Investigative Drug 2,7-Bis[3-(butylamino)propionamido]anthraquinone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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