CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD543
Family Name Multidrug resistance protein Inhibitor Curcumin I Family
No. of Seeds 19 No. of Other Members 278
Family Centroid CFAMM00163928 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Aldehyde oxidase Inhibitor Isovanillin Superfamily
Class Class 663

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand steroid Estradiol Family 18 147
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor ligand Dienestrol Family 35 440
DNA Binder Methoxsalen Family 10 1638
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Salicin family 5 629
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
D(3) dopamine receptor Ligand U-99194A Family 7 33
Oxi4503 family 4 27
TS-071 family 8 36
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Glucose-6-phosphate translocase Inhibitor Kodaistatin A Family 1 0
Integrase Inhibitor L-708,906 Family 1 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Endothelin-1 receptor Ligand PD156707 Family 41 211
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor Fila... 9 9
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU78300 F... 1 2
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benz... 2 6
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Epidermal growth factor receptor Ligand 2-cyano-3-(3,4-dihydro... 1 0
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Tubulin beta chain Inhibitor 3-bromo-4,4',5-trimethoxy-(z)-sti... 1 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Neutrophil elastase Inhibitor Bornyl (3,4,5-trihydroxy)-cinnam... 1 0
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Epidermal growth factor receptor Ligand 4-(2-nitrovinyl)benzen... 3 1
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Carbonic anhydrase 2 Inhibitor Guaiacol Family 1 14
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Aromatase Inhibitor NSC-122427 Family 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Beta-secretase 1 Inhibitor Eckol Family 6 40
Tyrosine-protein phosphatase non-receptor type 1 Ligand Formyl... 1 1
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Transient receptor potential cation channel subfamily V member... 2 6
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Transient receptor potential cation channel subfamily V member... 14 7
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 4 2
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 0
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Acetylcholinesterase inhibitor 5,7-Dimethoxy-2-methyl-indan-1-... 1 0
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Putative fructose-1,6-bisphosphate aldolase and Retinal dehydr... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 3
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Integrase inhibitor AC1O6FK1 family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E,... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Fyn in... 1 2
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
Receptor-type tyrosine-protein phosphatase C and Tyrosine-prot... 1 0
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial ... 1 1
Epidermal growth factor receptor ligand NSC650565 family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Steroids and Steroid Derivatives Metabolite Oryzanol C Family 5 2
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Phenols and Derivatives Metabolite 6-Gingesulfonic acid Family 1 2
Prenol Lipids Metabolite Rosmadial Family 1 0
Acenes Metabolite Musanolone D Family 2 1
Benzene and Substituted Derivatives Metabolite 1,3,5-Trimethox... 2 17
Putative NP ZINC31165975 Family 4 0
2-benzoyl-3-(3,4-dimethoxyphenyl)-2-ethylcyclopropane-1,1-dica... 4 0
Putative NP ZINC04012191 Family 2 2
NP 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-ethyl-4-oxo-4h-ch... 33 4
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-6-ethyl-4... 10 0
NP (1r,2r,4s)-2-(2-methoxyphenyl)-1,3,3-trimethylbicyclo[2.2.1... 3 0
7,8-dimethoxy-1-oxoisothiochromene-3-carboxylate NP Methyl 7,8... 2 0
3-(2,3-dihydro-1,4-benzodioxin-6-yl)chromene-4-thione NP 3-(2,... 1 0
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
NP 4-(3,4-dimethoxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)but... 2 3
Putative NP ZINC00518618 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00163928 DCL001107 Clinical Trial Drug Curcumin I
CFAMM00164015 DNC008600 Investigative Drug 5-octyl-2-phenoxyphenol
CFAMM00164443 DNC006898 Investigative Drug DEHYDROZINGERONE
CFAMM00164635 DNC012860 Investigative Drug DEMETHOXYCURCUMIN
CFAMM00164258 DNC010687 Investigative Drug EUGENOL
CFAMM00164366 DNC008489 Investigative Drug 5-hexyl-2-phenoxyphenol
CFAMM00164629 DNC013712 Investigative Drug 2,3-dimethoxy-2'-hydroxychalcone
CFAMM00164301 DNC014596 Investigative Drug COMBETASTATIN
CFAMM00164153 DNC008723 Investigative Drug Go-Y026
CFAMM00164033 DNC007546 Investigative Drug ENDIANDRIN A
CFAMM00164131 DNC011316 Investigative Drug NSC-381864
CFAMM00164472 DNC010392 Investigative Drug acerogenin C
CFAMM00164151 DNC008725 Investigative Drug Go-Y022
CFAMM00164413 DNC009459 Investigative Drug p-hydroxyphenethyl trans-ferulate
CFAMM00164329 DNC010453 Investigative Drug FERULIC ACID
CFAMM00163945 DNC009184 Investigative Drug dimethylnordihydroguarierate acid
CFAMM00164637 DNC002622 Investigative Drug 5-PENTYL-2-PHENOXYPHENOL
CFAMM00164320 DNC006900 Investigative Drug CURCUMIN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26384 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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