CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD548
Family Name Histone deacetylase 1 Inhibitor Pyroxamide Family
No. of Seeds 4 No. of Other Members 13
Family Centroid CFAMM00164738 Functional Category Clinical Trial Drug
Superfamily Prothrombin Inhibitor Ximelegatran Superfamily
Class Class 705

Cousin Family NamesSeedsMembers
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Class II cytokine receptor Ligand IL-10 Family 7 45
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Aromatase Inhibitor Rogletimide Family 1 2
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Transient receptor potential cation channel subfamily V member... 2 26
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Farnesyl pyrophosphate synthase inhibitor AC1NQOV1 family 2 1
D-amino-acid oxidase and D-aspartate oxidase inhibitor naphthy... 2 2
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 2
Sterol O-acyltransferase 1 inhibitor Decanamide, 2-(hexylthio)... 1 3
Hormone-sensitive lipase inhibitor AGN-PC-074W3L family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00164738 DCL001119 Clinical Trial Drug Pyroxamide
CFAMM00164726 DNC004621 Investigative Drug Octanedioic acid hydroxyamide pyridin-4-ylamide
CFAMM00164724 DNC004625 Investigative Drug Octanedioic acid hydroxyamide pyridin-2-ylamide
CFAMM00164729 DNC004811 Investigative Drug 7-Mercapto-heptanoic acid pyridin-3-ylamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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