CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD557
Family Name NS5A protein Inhibitor Bms 790052 Family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00164862 Functional Category Clinical Trial Drug
Superfamily NS5A protein Inhibitor Bms 790052 Superfamily
Class Class 1170

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Epidermal Growth Factor family 111 209
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Prothrombin Inhibitor Dabigatran Family 7 182
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
BIBT986 family 7 96
CBP-501 family 7 8
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
C-X-C chemokine receptor type 2 Ligand Sb 272844 Family 7 3
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Serine/threonine-protein kinase Chk1 Inhibitor Granulatimide F... 1 1
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN9... 3 10
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Type-1 angiotensin II receptor ligand 7-methyl-N-(2-phenylethy... 2 10
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1-phenylimidaz... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Gastrin/cholecystokinin type B receptor ligand CHEMBL2386886 f... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Gastrin-releasing peptide receptor ligand (2S)-N-[(2S)-1-[[(2S... 1 0
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[[3-(2-aminoet... 8 7
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Melanocortin receptor 3 and Melanocyte-stimulating hormone rec... 2 3
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935256 family 1 0
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor (2S)... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00164872 CHEMBL386993 Bioactive N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[(2R)-2-[[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]methyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
CFAMM00164863 CHEMBL386478 Bioactive (2S)-N-[(2R)-1-[[(2S)-1-[(2R)-2-[[[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]methyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-(3-phenylpropanoylamino)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-methylbutanamide
CFAMM00164875 CHEMBL414356 Bioactive (2S)-N-[(2R)-1-[[(2S)-1-[(2R)-2-[[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]methyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-methylbutanamide
CFAMM00164874 CHEMBL2370862 Bioactive (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[(2R)-2-[[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]methyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methylbutanamide
CFAMM00164862 DCL001161 Clinical Trial Drug BMS 790052

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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