CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD563
Family Name Dual specificity mitogen-activated protein kinase kinase Inhibitor GDC-0973 Family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00165036 Functional Category Clinical Trial Drug
Superfamily 5-hydroxytryptamine 2 receptor Ligand Ketanserin Superfamily
Class Class 664

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Dual specificity mitogen-activated protein kinase kinase Inhib... 5 13
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Mitogen-activated protein kinase kinase kinase 1 and Mitogen-a... 1 0
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00165042 CHEMBL2146893 Bioactive [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(propan-2-ylamino)methyl]azetidin-1-yl]methanone
CFAMM00165033 CHEMBL2146895 Bioactive [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-[(dimethylamino)methyl]-3-hydroxyazetidin-1-yl]methanone
CFAMM00165041 CHEMBL2146892 Bioactive [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-(ethylaminomethyl)-3-hydroxyazetidin-1-yl]methanone
CFAMM00165040 CHEMBL2146894 Bioactive [3-[(tert-butylamino)methyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone
CFAMM00165030 CHEMBL2146888 Bioactive [3-(aminomethyl)-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone
CFAMM00165039 CHEMBL2146896 Bioactive [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(pyrrolidin-1-ylmethyl)azetidin-1-yl]methanone
CFAMM00165037 CHEMBL2146898 Bioactive [3-[(1S)-1-aminoethyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone
CFAMM00165036 DCL001188 Clinical Trial Drug GDC-0973

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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