CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD6
Family Name Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family
No. of Seeds 2 No. of Other Members 75
Family Centroid CFAMM00126860 Functional Category Clinical Trial Drug
Superfamily Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Superfamily
Class Class 817

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Aurora kinase A Inhibitor ABT-348 Family 20 49
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase Inhibitor PT-109 Family 6 7
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 2
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
BDNF/NT-3 growth factors receptor and Aurora kinase A ligand S... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Tyrosyl-DNA phosphodiesterase 1 and ATP-dependent molecular ch... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00126876 CHEMBL513078 Bioactive AGN-PC-04X1WX
CFAMM00126860 DCL000006 Clinical Trial Drug SNS-314

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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