CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD61
Family Name Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family
No. of Seeds 32 No. of Other Members 52
Family Centroid CFAMM00132129 Functional Category Clinical Trial Drug
Superfamily Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Superfamily
Class Class 864

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Salicin family 5 629
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Glucokinase Inhibitor R7201 Family 22 105
TS-071 family 8 36
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[4... 9 1
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-chloro-4... 2 0
Protein FimH and Type 1 fimbiral adhesin FimH inhibitor methyl... 1 5
Sodium/glucose cotransporter 1 and Sodium/glucose cotransporte... 4 1
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[3... 1 0
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 1 0
Amine oxidase [flavin-containing] B inhibitor 4-[4-[(3-chlorop... 2 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 6 6
Arachidonate 5-lipoxygenase inhibitor SureCN9727677 family 1 2
Acetylcholinesterase inhibitor (2R,3S,4S,5R,6S)-2-(hydroxymeth... 1 1
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole NP (3ar,5r,6s,6ar)... 18 6
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00132116 CHEMBL1808388 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-(2-cyclopropyloxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132122 CHEMBL565781 Bioactive SureCN1315518
CFAMM00132151 CHEMBL1819098 Bioactive CHEMBL1819098
CFAMM00132144 CHEMBL568164 Bioactive SureCN1034978
CFAMM00132157 CHEMBL1819093 Bioactive CHEMBL1819093
CFAMM00132156 CHEMBL1819095 Bioactive CHEMBL1819095
CFAMM00132169 CHEMBL1085691 Bioactive SureCN14108323
CFAMM00132107 CHEMBL1808390 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-(2-cyclopentyloxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132120 CHEMBL1819196 Bioactive CHEMBL1819196
CFAMM00132149 CHEMBL1163912 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-5-[(4-ethoxyphenyl)methyl]-2-(2-methoxyethyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132113 CHEMBL577354 Bioactive (2R,3'R,4'S,5'S,6'R)-6-chloro-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[3H-1-benzofuran-2,2'-oxane]-3',4',5'-triol
CFAMM00132155 CHEMBL1819094 Bioactive CHEMBL1819094
CFAMM00132168 CHEMBL566622 Bioactive (3S,3'R,4'S,5'S,6'R)-6-chloro-6'-(hydroxymethyl)-5-[(2-methoxy-3-methylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00132119 CHEMBL1819197 Bioactive CHEMBL1819197
CFAMM00132154 CHEMBL1819097 Bioactive CHEMBL1819097
CFAMM00132118 CHEMBL1808386 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-(2-prop-2-enoxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132140 CHEMBL1817684 Bioactive CHEMBL1817684
CFAMM00132153 CHEMBL1819096 Bioactive CHEMBL1819096
CFAMM00132166 CHEMBL1807541 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[2-(1-methylcyclopropyl)oxyethoxy]phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132117 CHEMBL1808389 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-(2-cyclobutyloxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132133 CHEMBL589305 Bioactive SureCN1551970
CFAMM00132172 CHEMBL585477 Bioactive SureCN1316313
CFAMM00132152 CHEMBL1819099 Bioactive CHEMBL1819099
CFAMM00132165 CHEMBL1807542 Bioactive (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-(2-prop-2-ynoxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00132179 CHEMBL1770246 Bioactive SureCN181113
CFAMM00132132 DNCL002855 Clinical Trial Drug Ertugliflozin/PF-04971729
CFAMM00132099 DCL000101 Clinical Trial Drug Dapagliflozin
CFAMM00132129 DNCL002850 Clinical Trial Drug Empagliflozin
CFAMM00132136 DNCL002843 Clinical Trial Drug Dapagliflozin/metformin
CFAMM00132096 DNC010957 Investigative Drug O-spiroketal glucoside

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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