CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD612
Family Name Microsomal triglyceride transfer protein large subunit Inhibitor SLX-4090 Family
No. of Seeds 3 No. of Other Members 103
Family Centroid CFAMM00166426 Functional Category Clinical Trial Drug with Natural Product
Superfamily Microsomal triglyceride transfer protein large subunit Inhibitor SLX-4090 Superfamily
Class Class 1003

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Peroxisome proliferator-activated receptor alpha Ligand Bezafi... 2 17
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Sigma non-opioid intracellular receptor 1 Ligand SSR-125047 Fa... 1 2
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Kappa-type opioid receptor Ligand ICI-204448 Family 7 26
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Prostaglandin D2 receptor 2 ligand SureCN137334 family 1 0
Pol polyprotein inhibitor KNI-1279 family 3 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Metabotropic glutamate receptor 2 ligand SureCN787402 family 1 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00166496 CHEMBL2181753 Bioactive 2-[3-[2-[[benzylcarbamoyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00166438 CHEMBL237730 Bioactive AGN-PC-006WEW
CFAMM00166426 DNCL001850 Clinical Trial Drug SLX-4090

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26186 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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