CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD627
Family Name Macitentan family
No. of Seeds 18 No. of Other Members 1
Family Centroid CFAMM00166736 Functional Category Clinical Trial Drug
Superfamily Macitentan Superfamily
Class Class 1208

Cousin Family NamesSeedsMembers
Endothelin B receptor and Endothelin-1 receptor ligand pyrimid... 22 180
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 17 3
Endothelin-1 receptor ligand AGN-PC-075B4O family 7 0
Endothelin-1 receptor ligand SureCN8801173 family 3 0
Endothelin-1 receptor ligand AGN-PC-00GZJQ family 12 0
Endothelin-1 receptor ligand SureCN8657460 family 1 0
Endothelin-1 receptor ligand AGN-PC-075B4U family 3 0
Endothelin-1 receptor ligand AGN-PC-00FQOK family 4 0
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 3 1
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 7 0
Endothelin-1 receptor and Endothelin B receptor ligand N-(benz... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00166722 CHEMBL334263 Bioactive SureCN8802029
CFAMM00166735 CHEMBL2163694 Bioactive N-[5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]butane-1-sulfonamide
CFAMM00166728 CHEMBL2165333 Bioactive N-(benzylsulfamoyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-chlorophenyl)pyrimidin-4-amine
CFAMM00166734 CHEMBL2163693 Bioactive N-[5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]propane-1-sulfonamide
CFAMM00166727 CHEMBL2165339 Bioactive 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(butylsulfamoyl)pyrimidin-4-amine
CFAMM00166733 CHEMBL2163690 Bioactive 6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-chlorophenyl)-N-(propylsulfamoyl)pyrimidin-4-amine
CFAMM00166726 CHEMBL2165338 Bioactive 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(ethylsulfamoyl)pyrimidin-4-amine
CFAMM00166740 CHEMBL2165326 Bioactive 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine
CFAMM00166732 CHEMBL2165337 Bioactive 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(methylsulfamoyl)pyrimidin-4-amine
CFAMM00166725 CHEMBL2165340 Bioactive 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(cyclopropylsulfamoyl)pyrimidin-4-amine
CFAMM00166731 CHEMBL2165336 Bioactive N-(benzylsulfamoyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-propan-2-ylphenyl)pyrimidin-4-amine
CFAMM00166724 CHEMBL2163689 Bioactive N-[5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]morpholine-4-sulfonamide
CFAMM00166737 CHEMBL2165331 Bioactive N-(benzylsulfamoyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-phenylpyrimidin-4-amine
CFAMM00166730 CHEMBL2165335 Bioactive N-(benzylsulfamoyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(4-ethylphenyl)pyrimidin-4-amine
CFAMM00166723 CHEMBL2163688 Bioactive 4-[[benzyl(methyl)sulfamoyl]amino]-5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidine
CFAMM00166729 CHEMBL2165334 Bioactive N-(benzylsulfamoyl)-5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-amine
CFAMM00166736 DNCL001904 Clinical Trial Drug Macitentan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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