CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD630
Family Name Metabotropic glutamate receptor 2 and Metabotropic glutamate receptor 3 Ligand BCI-632 Family
No. of Seeds 31 No. of Other Members 7
Family Centroid CFAMM00166774 Functional Category Clinical Trial Drug
Superfamily Metabotropic glutamate receptor 2 and Metabotropic glutamate receptor 3 Ligand BCI-632 Superfamily
Class Class 1210

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 2 ligand (1R,2R,3R,5R,6R)-2-am... 9 0
Metabotropic glutamate receptor 2 ligand (1R,2R,3R,5R,6R)-2-am... 2 0
Metabotropic glutamate receptor 2 ligand (1R,2R,3R,5R,6R)-2-am... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00166754 CHEMBL365680 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(1R)-1-(3,4-dichlorophenyl)butoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166781 CHEMBL359805 Bioactive (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3-methylphenyl)methoxy]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166768 CHEMBL362325 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(4-chloro-3-fluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166761 CHEMBL187482 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2,6-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166753 CHEMBL189814 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(4-chlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166767 CHEMBL188511 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2,4-difluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166780 CHEMBL434536 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-benzhydryloxy-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166760 CHEMBL359491 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(3-chloro-4-fluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166773 CHEMBL186107 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2,3-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166752 CHEMBL362092 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2-chlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166779 CHEMBL186214 Bioactive (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-phenylmethoxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166759 CHEMBL186630 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(3,4-difluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166772 CHEMBL185423 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(1S)-1-(3,4-dichlorophenyl)propoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166751 CHEMBL426983 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2,3-difluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166765 CHEMBL182972 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(1R)-1-(3,4-dichlorophenyl)ethoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166778 CHEMBL364320 Bioactive (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(2-phenylphenyl)methoxy]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166757 CHEMBL364201 Bioactive (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-(naphthalen-1-ylmethoxy)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166771 CHEMBL363980 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(3,5-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166784 CHEMBL184983 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(1R)-1-(3,4-dichlorophenyl)propoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166750 CHEMBL442967 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2,4-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166777 CHEMBL183073 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(1S)-1-(3,4-dichlorophenyl)ethoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166756 CHEMBL181710 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(1S)-1-(3,4-dichlorophenyl)butoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166770 CHEMBL365244 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[bis(4-chlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166783 CHEMBL188787 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(3-chlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166749 CHEMBL363724 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[bis(3,4-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166763 CHEMBL184504 Bioactive (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3-phenylphenyl)methoxy]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166755 CHEMBL189139 Bioactive SureCN4964079
CFAMM00166769 CHEMBL359905 Bioactive (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3,4,5-trichlorophenyl)methoxy]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166782 CHEMBL361051 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[(2,6-difluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166775 CHEMBL363696 Bioactive (1R,2R,3R,5R,6R)-2-amino-3-[bis(4-fluorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CFAMM00166774 DNCL001926 Clinical Trial Drug BCI-632

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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