CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD631
Family Name Irdabisant family
No. of Seeds 49 No. of Other Members 53
Family Centroid CFAMM00166869 Functional Category Clinical Trial Drug with Natural Product
Superfamily Irdabisant Superfamily
Class Class 1211

Cousin Family NamesSeedsMembers
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Histamine H1 receptor and Histamine H3 receptor Ligand GSK1004... 13 18
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA5P family 4 11
Histamine H3 receptor ligand SureCN4319687 family 8 15
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Histone deacetylase 2 and Histone deacetylase 3 inhibitor N'-h... 1 2
Histamine H3 receptor ligand SureCN1373218 family 2 2
Histamine H3 receptor ligand 6-[3-chloro-4-[3-[(2R)-2-methylpy... 1 0
Histamine H3 receptor ligand 2-methyl-4-[4-(3-pyrrolidin-1-ylp... 4 1
Histamine H3 receptor ligand 3-methyl-1-[4-(3-piperidin-1-ylpr... 6 1
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Histamine H3 receptor ligand (4R)-3-[4-(1-cyclobutylpiperidin-... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 7 13
5-hydroxytryptamine receptor 3A ligand 5-[4-[3-(azepan-1-yl)pr... 2 0
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 5 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and Sodium-dep... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor (4aS... 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00166826 CHEMBL2031474 Bioactive 8-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]-5,6-dihydro-2H-benzo[h]cinnolin-3-one
CFAMM00166792 CHEMBL1935100 Bioactive 3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-4,5-dihydro-1H-pyridazin-6-one
CFAMM00166856 CHEMBL1950734 Bioactive 3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-4-methyl-1H-pyridazin-6-one
CFAMM00166805 CHEMBL1935114 Bioactive 5,5-dimethyl-3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1,4-dihydropyridazin-6-one
CFAMM00166819 CHEMBL1958133 Bioactive 2-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166832 CHEMBL1958325 Bioactive 4-[4-[3-(azepan-1-yl)propoxy]phenyl]-3-methyl-1H-pyridazin-6-one
CFAMM00166848 CHEMBL1958326 Bioactive 2,6-dimethyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166798 CHEMBL1823403 Bioactive 6-[4-(1-cyclopentylpiperidin-4-yl)oxyphenyl]-2-methylpyridazin-3-one
CFAMM00166811 CHEMBL1813055 Bioactive 3-[4-(3-piperidin-1-ylpropoxy)phenyl]-1H-pyridazin-6-one
CFAMM00166876 CHEMBL1950742 Bioactive 3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-4,5-dihydro-1H-pyridazin-6-one
CFAMM00166882 CHEMBL1813063 Bioactive 6-[4-[3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy]phenyl]-2-methylpyridazin-3-one
CFAMM00166804 CHEMBL1935111 Bioactive 4-methyl-3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-4,5-dihydro-1H-pyridazin-6-one
CFAMM00166831 CHEMBL1958324 Bioactive 3-methyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]-1H-pyridazin-6-one
CFAMM00166846 CHEMBL1835786 Bioactive 2-methyl-4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-5,6,7,8-tetrahydrophthalazin-1-one
CFAMM00166797 CHEMBL1823402 Bioactive 6-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2-methylpyridazin-3-one
CFAMM00166839 CHEMBL2037608 Bioactive 2-(methoxymethyl)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166790 CHEMBL1945844 Bioactive 4-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-1H-pyridazin-6-one
CFAMM00166803 CHEMBL1935110 Bioactive 5-methyl-3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-4,5-dihydro-1H-pyridazin-6-one
CFAMM00166867 CHEMBL1829485 Bioactive 2-methyl-6-[4-[(2S)-2-methyl-3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166881 CHEMBL2037609 Bioactive 4-methoxy-2-(methoxymethyl)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166845 CHEMBL1835782 Bioactive 3-methyl-1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one
CFAMM00166874 CHEMBL1923728 Bioactive 5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridin-2-one
CFAMM00166837 CHEMBL1958323 Bioactive 3-methyl-4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
CFAMM00166789 CHEMBL1945845 Bioactive 4-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-3-methyl-1H-pyridazin-6-one
CFAMM00166816 CHEMBL1829337 Bioactive 2-(2-fluoroethyl)-6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166844 CHEMBL1829475 Bioactive 4-methyl-3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
CFAMM00166822 CHEMBL2031470 Bioactive 2-methyl-8-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]-5,6-dihydrobenzo[h]cinnolin-3-one
CFAMM00166886 CHEMBL2037604 Bioactive 4-[4-[(2S)-2-methyl-3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
CFAMM00166808 CHEMBL1813059 Bioactive 6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-propan-2-ylpyridazin-3-one
CFAMM00166836 CHEMBL1958322 Bioactive 5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-propan-2-ylpyridazin-3-one
CFAMM00166865 CHEMBL1829481 Bioactive 3-[3,5-difluoro-4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
CFAMM00166828 CHEMBL2031476 Bioactive 8-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]-5,6-dihydro-3H-benzo[f]cinnolin-2-one
CFAMM00166843 CHEMBL1829477 Bioactive 6-[3-fluoro-4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-methylpyridazin-3-one
CFAMM00166794 CHEMBL1950643 Bioactive 3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-1H-pyridazin-6-one
CFAMM00166821 CHEMBL1950646 Bioactive 2-methyl-6-[4-(1-propan-2-ylpiperidin-4-yl)oxyphenyl]pyridazin-3-one
CFAMM00166850 CHEMBL1829469 Bioactive 2-(2-hydroxyethyl)-6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166834 CHEMBL1958327 Bioactive 2,6-dimethyl-5-[4-(3-piperidin-1-ylpropoxy)phenyl]pyridazin-3-one
CFAMM00166813 CHEMBL1813057 Bioactive 2-methyl-6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
CFAMM00166787 CHEMBL1945847 Bioactive 5-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2,6-dimethylpyridazin-3-one
CFAMM00166842 CHEMBL1829473 Bioactive 5-methyl-3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
CFAMM00166793 CHEMBL1950644 Bioactive 3-[4-(1-cyclopentylpiperidin-4-yl)oxyphenyl]-1H-pyridazin-6-one
CFAMM00166884 CHEMBL1813065 Bioactive 4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
CFAMM00166849 CHEMBL1829468 Bioactive 6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-(2,2,2-trifluoroethyl)pyridazin-3-one
CFAMM00166869 DNCL001939 Clinical Trial Drug Irdabisant

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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