CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD632
Family Name MK-3328 family
No. of Seeds 2 No. of Other Members 32
Family Centroid CFAMM00166912 Functional Category Clinical Trial Drug
Superfamily MK-3328 Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Hepatocyte growth factor receptor ligand 2-[2-amino-5-(1-piper... 4 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
Mitogen-activated protein kinase kinase kinase 7 and TGF-beta-... 3 14
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (3R,4S... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00166913 CHEMBL366539 Bioactive 5-[7-(1-benzyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl)-[1,3]oxazolo[5,4-d]pyrimidin-2-yl]-N,N-dimethylpyridin-2-amine
CFAMM00166912 DNCL001964 Clinical Trial Drug MK-3328

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42616 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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