CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD64
Family Name Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031 Family
No. of Seeds 3 No. of Other Members 206
Family Centroid CFAMM00132290 Functional Category Clinical Trial Drug with Natural Product
Superfamily Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031 Superfamily
Class Class 866

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Neuromedin-K receptor Ligand Talnetant Family 3 49
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Leukotriene B4 receptor 1 Ligand SB-209247 Family 7 24
Leukotriene B4 receptor 1 Ligand SB-201146 Family 3 18
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Metabotropic glutamate receptor 5 Ligand 2-phenylethynyl-5,6,7... 1 4
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Cysteinyl leukotriene receptor 1 ligand 3-[1-[3-[(7-chloroquin... 5 6
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Cysteinyl leukotriene receptor 1 ligand SureCN7008285 family 12 97
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-met... 3 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 5-[2-... 7 1
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 22 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 2
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Type-1B angiotensin II receptor ligand AGN-PC-040VXR family 6 15
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-04XS1Y f... 1 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Reverse transcriptase/RNaseH inhibitor 3-(4-cyclopropyl-1,1,1-... 2 2
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Nuclear receptor ROR-gamma and Ras-related protein Rab-9A liga... 1 0
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[cyclohexyl-[5-(q... 1 0
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[cyclohexyl-[4-[(... 4 0
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 4
Gonadotropin-releasing hormone receptor ligand 3-(3,5-dimethyl... 1 3
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
2,4,6-trimethyl-2,3-dihydrofuro[3,2-c]quinoline NP ZINC0009476... 4 0
NP (2r,3r,4s,5r)-2-(acetoxymethyl)-6-(quinolin-8-yloxy)tetrahy... 2 1
3-quinolin-2-ylchromen-2-one NP ZINC08690002 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00132276 DCL000468 Clinical Trial Drug AZD4769
CFAMM00132290 DCL000104 Clinical Trial Drug DG031
CFAMM00132454 DNC011978 Investigative Drug REV-5901

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

71835 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 
Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543