CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Prostaglandin E2 receptor EP3 subtype Ligand DG041 Family
No. of Seeds 9 No. of Other Members 16
Family Centroid CFAMM00132495 Functional Category Clinical Trial Drug
Superfamily Prostaglandin E2 receptor EP3 subtype Ligand DG041 Superfamily
Class Class 867

Cousin Family NamesSeedsMembers
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
NF-kappa-B Inhibitor 5-bromo-n-(quinolin-8-yl)thiophene-2-sulf... 2 5
5-hydroxytryptamine receptor 6 ligand SureCN3147604 family 7 6
5-hydroxytryptamine receptor 6 ligand 1-(5-bromothiophen-2-yl)... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Prostaglandin E2 receptor EP3 subtype ligand N-(4,5-dichloroth... 3 0


External ID

Functional Category

Molecule Name

CFAMM00132514 CHEMBL585581 Bioactive (E)-3-[1-[(2,4-dichlorophenyl)methyl]indol-7-yl]-N-thiophen-2-ylsulfonylprop-2-enamide
CFAMM00132498 CHEMBL585099 Bioactive (E)-3-[1-[(2,4-dichlorophenyl)methyl]-3-methylindol-7-yl]-N-thiophen-2-ylsulfonylprop-2-enamide
CFAMM00132504 CHEMBL565799 Bioactive (E)-N-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[5-fluoro-3-methyl-1-(naphthalen-2-ylmethyl)indol-7-yl]prop-2-enamide
CFAMM00132497 CHEMBL566421 Bioactive (E)-N-(4,5-dichlorothiophen-2-yl)sulfonyl-3-[1-methyl-3-(naphthalen-2-ylmethyl)indol-4-yl]prop-2-enamide
CFAMM00132510 CHEMBL566005 Bioactive (E)-3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-N-(3,5-difluorophenyl)sulfonylprop-2-enamide
CFAMM00132503 CHEMBL1080619 Bioactive AGN-PC-07Z9DF
CFAMM00132509 CHEMBL584488 Bioactive (E)-3-[1-[(4-cyanophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-N-(4,5-dichlorothiophen-2-yl)sulfonylprop-2-enamide
CFAMM00132508 CHEMBL566006 Bioactive SureCN1137709
CFAMM00132495 DCL000105 Clinical Trial Drug DG041

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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