CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD654
Family Name Tivozanib family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00167266 Functional Category Clinical Trial Drug with Natural Product
Superfamily Hepatocyte growth factor receptor and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 938

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
8-aminoquinoline Inhibitor Tafenoquine Family 1 0
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor CHEMBL1395532 family 1 10
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Platelet-derived growth factor receptor beta ligand N-(4,5-dim... 5 1
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00167268 CHEMBL279351 Bioactive AGN-PC-007DKM
CFAMM00167263 CHEMBL2023477 Bioactive 2-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)acetamide
CFAMM00167266 DNCL002107 Clinical Trial Drug Tivozanib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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