CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD656
Family Name DCC-2036 family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00167288 Functional Category Clinical Trial Drug
Superfamily DCC-2036 Superfamily
Class Class 918

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Coagulation factor X Inhibitor Apixaban Family 34 52
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Smoothened homolog Inhibitor LDE225 Family 3 76
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Neuropeptide Y receptor type 5 ligand 3-[1-(2-fluorophenyl)pyr... 2 0
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
Coagulation factor X inhibitor SureCN6785555 family 7 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Coagulation factor X inhibitor SureCN5641901 family 5 0
Coagulation factor X inhibitor AGN-PC-077MYE family 16 0
Coagulation factor X inhibitor SureCN5644036 family 30 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-073M5F fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00167286 CHEMBL1213974 Bioactive AGN-PC-00IJY4
CFAMM00167288 DNCL002117 Clinical Trial Drug DCC-2036

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24732 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543