CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD661
Family Name Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family
No. of Seeds 12 No. of Other Members 135
Family Centroid CFAMM00167630 Functional Category Clinical Trial Drug with Natural Product
Superfamily Serine/threonine-protein kinase mTOR Inhibitor CC-223 Superfamily
Class Class 1230

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Fludi... 11 78
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Androgen receptor Ligand LG-121071 Family 8 32
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Sphingosine kinase 2 Inhibitor (r)-2-amino-4-hydroxy-n-(4-octy... 3 9
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor AGN-PC-00QIZ9 family 2 15
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Androgen receptor and Progesterone receptor ligand (5bR,9aR)-1... 1 0
Equilibrative nucleoside transporter 1 inhibitor Draflazine fa... 1 8
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-044QVW fa... 10 1
Neuropeptide Y receptor type 5 ligand 2-(5-fluoro-2,3-dihydroi... 4 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 1 2
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Transient receptor potential M8 protein ligand 2-(4-bromopheny... 1 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Progesterone receptor ligand CHEMBL403139 family 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Dipeptidyl peptidase 4 inhibitor (2S,4S)-1-[2-[[1-[4-cyano-2-(... 2 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Cathepsin K and Cathepsin B inhibitor AGN-PC-076LFZ family 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Progesterone receptor ligand SureCN3031001 family 8 40
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Microbial collagenase inhibitor AGN-PC-00F17U family 1 1
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 2 2
Amyloid beta A4 protein inhibitor (2S,3R)-3-(2-methylpropyl)-N... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-meth... 7 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Peptide deformylase inhibitor 2-(5-bromo-2,2-dioxo-1,4-dihydro... 3 1
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Glutamate receptor 1 and Glutamate receptor 2 ligand SureCN909... 1 0
Substance-P receptor ligand (2S)-2-N-[2-[(3,5-dimethylphenyl)m... 1 1
Putative NP ZINC55466512 Family 2 0
NP Tert-butyl ((s)-3-methyl-1-oxo-1-(4-(((s)-1-oxo-1-(p-tolyla... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00167699 CHEMBL105454 Bioactive 1-[(2R)-2-methyl-2,3-dihydroindol-1-yl]-2-[4-[[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]ethanone
CFAMM00167614 CHEMBL521605 Bioactive N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(4-fluoro-2-methylphenyl)-N-methylpiperazine-2-carboxamide
CFAMM00167634 CHEMBL2218460 Bioactive SureCN3729113
CFAMM00167610 CHEMBL184158 Bioactive 2-[4-(2-cyano-4-tritiophenyl)piperazin-1-yl]-N-(3-methyl-2,4,6-tritritiophenyl)acetamide
CFAMM00167548 CHEMBL219129 Bioactive SureCN4003724
CFAMM00167535 CHEMBL362542 Bioactive 1-Piperazineacetamide, 4-(2-cyanophenyl)-N-(3-methylphenyl)-
CFAMM00167630 DNCL002142 Clinical Trial Drug CC-223

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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