CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 Inhibitor AZD1480 Family
No. of Seeds 15 No. of Other Members 12
Family Centroid CFAMM00167769 Functional Category Clinical Trial Drug
Superfamily Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 Inhibitor AZD1480 Superfamily
Class Class 1232

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Tyrosine-protein kinase JAK2 inhibitor SureCN217071 family 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
BDNF/NT-3 growth factors receptor and NT-3 growth factor recep... 3 4
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0


External ID

Functional Category

Molecule Name

CFAMM00167759 CHEMBL1650725 Bioactive SureCN218888
CFAMM00167773 CHEMBL1650730 Bioactive SureCN218749
CFAMM00167758 CHEMBL1650697 Bioactive SureCN217992
CFAMM00167772 CHEMBL1650733 Bioactive SureCN220017
CFAMM00167751 CHEMBL2381979 Bioactive 5-fluoro-4-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-2-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidine-2,4-diamine
CFAMM00167764 CHEMBL570002 Bioactive SureCN14041535
CFAMM00167757 CHEMBL1650729 Bioactive SureCN3345208
CFAMM00167771 CHEMBL1650732 Bioactive SureCN220863
CFAMM00167763 CHEMBL2381985 Bioactive 4-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-2-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidine-2,4-diamine
CFAMM00167749 CHEMBL569720 Bioactive 3-[[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]amino]-6-methyl-5-[(5-methyl-1H-pyrazol-3-yl)amino]pyrazine-2-carbonitrile
CFAMM00167762 CHEMBL1650726 Bioactive SureCN4006062
CFAMM00167768 CHEMBL570899 Bioactive 2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-6-N-(5-methyl-1H-pyrazol-3-yl)pyrazine-2,6-diamine
CFAMM00167775 CHEMBL1650734 Bioactive 5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidine-2,4-diamine
CFAMM00167760 CHEMBL1650724 Bioactive SureCN217828
CFAMM00167769 DNCL002157 Clinical Trial Drug AZD1480

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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